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| | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Basic information |
| Product Name: | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE | | Synonyms: | (R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetylchloride;(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%;(R)-(-)-MTPA-Cl, Moshers acid chloride;(S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionic acid chloride;(S)-2-Methoxy-3,3,3-trifluoro-2-phenylpropionic acid chloride;(S)-2-Phenyl-2-methoxy-3,3,3-trifluoropropionic acid chloride;[S,(+)]-α-Methoxy-α-(trifluoromethyl)benzeneacetic acid chloride;(R)-(-)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+% | | CAS: | 39637-99-5 | | MF: | C10H8ClF3O2 | | MW: | 252.62 | | EINECS: | 621-758-4 | | Product Categories: | Analytical Chemistry;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination | | Mol File: | 39637-99-5.mol |  |
| | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties |
| alpha | D25 -10.0± 0.1° (neat, l = 1) | | Boiling point | 213-214 °C(lit.) | | density | 1.35 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.469(lit.) | | Fp | 194 °F | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | form | Liquid | | color | Clear colorless to light yellow | | Specific Gravity | 1.353 | | optical activity | [α]20/D 137±2°, c = 6.4% in carbon tetrachloride | | Water Solubility | Sparingly miscible with water. | | Sensitive | Moisture Sensitive | | Merck | 14,6280 | | BRN | 3591565 | | CAS DataBase Reference | 39637-99-5(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | F | 10-21 | | Hazard Note | Corrosive/Freeze | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29189900 |
| | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow liquid | | Uses | (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids. | | Purification Methods | The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.] |
| | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials |
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