ChemicalBook Product Catalog Chemical Reagents Organic reagents Fatty alcohols 4-Chlorobenzhydrol

4-Chlorobenzhydrol

4-Chlorobenzhydrol Basic information
Product Name:4-Chlorobenzhydrol
Synonyms:(4-Chlorophenyl)phenylmethanol;4-chloro-alpha-phenyl-benzenemethano;4-Chlorobenzohydrol;Benzhydrol, 4-chloro-;Benzhydrol, p-chloro-;AURORA KA-7061;P-CHLORO BENZHYDROL;4-CHLOROPHENYL PHENYL CARBINOL
CAS:119-56-2
MF:C13H11ClO
MW:218.68
EINECS:204-333-4
Product Categories:Building Blocks;C11 to C30+;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Pharmaceutical Intermediate;Benzhydrols, Benzyl & Special Alcohols;Alcohols;C9 to C30;Oxygen Compounds
Mol File:119-56-2.mol
4-Chlorobenzhydrol Structure
4-Chlorobenzhydrol Chemical Properties
Melting point 58-60 °C (lit.)
Boiling point 150-151°C 2,6mm
density 1.1178 (rough estimate)
refractive index 1.5260 (estimate)
Fp 150-151°C/2.6mm
storage temp. 2-8°C
solubility insoluble
form neat
pka13.34±0.20(Predicted)
color White to Off-White
Water Solubility insoluble
BRN 2050235
CAS DataBase Reference119-56-2(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenemethanol, 4-chloro-«alpha»-phenyl-(119-56-2)
EPA Substance Registry SystemBenzenemethanol, 4-chloro-.alpha.-phenyl- (119-56-2)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
TSCA Yes
HS Code 29062990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
4-Chlorobenzhydrol Usage And Synthesis
Chemical Propertieswhite crystalline powder
Uses4-Chlorobenzhydrol was used as internal standard to measure the N-demethyl antipyrine metabolite in urine by gas chromatography-mass spectrometry. It was also used in the identification of the antihistamine cetirizine as a relevant cross-reactant for the carbamazepine-specific enzyme-linked immunosorbent assay .
DefinitionChEBI: P-Chlorobenzhydrol is a diarylmethane.
PreparationPreparation of 4-Chlorobenzhydrol(4-CB):
about 5.0g(0.023 mol) of 4-chloro benzophenone was dissolved in 15 mL of isopropyl alcohol (IPA) and heated to 50°C followed by the addition of 0.265g(0.007 mol) of sodium borohydride as a lot with the temperature maintained at 65°C for 2 h. The reaction mixture was distilled to expel isopropyl alcohol up to 90 %. The resulting solution was cooled and treated with dil HCl (5 mL of conc. HCl in 20 mL of water). Finally the reaction mass was extracted with 15 mL of toluene. The toluene extract was washed withwater to pH-7. The compound obtained in this step was taken to next step without isolation but aliquot sample was concentrated, isolated and checked for melting point (m.p. = 58-60°C).
1,1-BIS(4-CHLOROPHENYL)-2-[(4-CHLOROPHENYL)SULFONYL]-1-ETHANOL 4,4'-DICHLORO-ALPHA-METHYLBENZHYDROL ROSE BENGAL FLUORESCEIN CHLORIDE 2-(BENZYLSULFANYL)-1,1-BIS(4-CHLOROPHENYL)-1-ETHANOL 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN 4,4',4''-TRICHLOROTRITYL ALCOHOL 1,1-BIS(4-CHLOROPHENYL)-2-[(2-CHLOROPHENYL)SULFANYL]-1-ETHANOL 1,1-BIS(4-CHLOROPHENYL)-2-[(2-CHLOROPHENYL)SULFONYL]-1-ETHANOL Chlorthalidone 1,1-BIS(4-CHLOROPHENYL)-2-[(4-CHLOROPHENYL)SULFANYL]-1-ETHANOL CHLOROPROPYLATE ROSE BENGAL Cloperastine hydrochloride 2-[(4-CHLOROBENZYL)SULFANYL]-1,1-BIS(4-CHLOROPHENYL)-1-ETHANOL Acid Red 92 2-[(4-CHLOROBENZYL)SULFINYL]-1,1-BIS(4-CHLOROPHENYL)-1-ETHANOL ROSE BENGAL LACTONE
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