|
| | Catalpol Basic information |
| Product Name: | Catalpol | | Synonyms: | CATALPOL;CATAPOL;,6-beta,6a-alpha))-;beta-d-glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl);catalpinoside;de(p-hydroxybenzoyl)catalposide;des-p-hydroxybenzoyl-catalposid;oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1as-(1a-alpha,1b-beta,2-beta,5a-beta | | CAS: | 2415-24-9 | | MF: | C15H22O10 | | MW: | 362.33 | | EINECS: | 219-324-0 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Iridoids | | Mol File: | 2415-24-9.mol |  |
| | Catalpol Chemical Properties |
| Melting point | 203-205°C | | Boiling point | 675.6±55.0 °C(Predicted) | | density | 1.72±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) | | form | Solid | | pka | 12.79±0.70(Predicted) | | color | White to Off-White | | InChIKey | LHDWRKICQLTVDL-CLLMHHLUSA-N | | LogP | -4.609 (est) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | LZ5776816 | | HS Code | 29389090 | | Toxicity | mouse,LD,intravenous,> 2500mg/kg (2500mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 93, 1968. |
| | Catalpol Usage And Synthesis |
| Description | Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties. It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 μM. Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 μg/ml and 25 to 100 mg/kg, respectively. In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain. | | Chemical Properties | Light brown powder | | Uses | Catapol is an iridoid glucoside that has been shown to alleviate neuropathic pain. | | Definition | ChEBI: Catalpol is an organic molecular entity. It has a role as a metabolite. |
| | Catalpol Preparation Products And Raw materials |
|
