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| | 7,8-Dihydro-14-hydroxy- normorphinone Basic information |
| Product Name: | 7,8-Dihydro-14-hydroxy- normorphinone | | Synonyms: | 4,5α-Epoxy-3,14-dihydroxymorphinan-6-one;(5α)-4,5-epoxy-3,14-dihydroxymorphinan-6-one;NoroxyMorphone HCl;Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-, (5a)-;Noroxymorphone hydrochloride solution
;Methanol(test NoroxymorphoneHCl,100μg/mLasfreebase);Naloxone HCl Impurity;Naltrexone EP Impurity B | | CAS: | 33522-95-1 | | MF: | C16H17NO4 | | MW: | 287.32 | | EINECS: | 251-561-5 | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals | | Mol File: | 33522-95-1.mol |  |
| | 7,8-Dihydro-14-hydroxy- normorphinone Chemical Properties |
| Melting point | >265°C (dec.) | | Boiling point | 552.1±50.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | Fp | 22℃ | | storage temp. | Controlled Substance, -20°C Freezer | | solubility | DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml | | form | A crystalline solid | | pka | 9.20±0.40(Predicted) | | Stability: | Hygroscopic |
| Hazard Codes | T,F | | Risk Statements | 10-23/24/25-39/23/24/25-11 | | Safety Statements | 36/37-45-16-7 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 1 | | DEA Controlled Substances | CSCN: 9668
CSA SCH: Schedule II
NARC: Yes |
| | 7,8-Dihydro-14-hydroxy- normorphinone Usage And Synthesis |
| Description | Noroxymorphone (Item No. 15903) is an analytical reference standard that is structurally categorized as an opioid. It is an active metabolite of oxycodone , noroxycodone (Item Nos. 15902 | 20407), and oxymorphone that can be detected in plasma and urine. Noroxymorphone is also an immediate precursor in the synthesis of several opioids, including naltrexone (Item Nos. 15520 | ISO60192) and naloxone (Item Nos. 15594 | ISO60191). Noroxymorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications. | | Chemical Properties | Off-White to Light Brown Solid | | Uses | A metabolite of Naloxone and Naltrexone | | Definition | ChEBI: Noroxymorphone is a member of phenanthrenes. |
| | 7,8-Dihydro-14-hydroxy- normorphinone Preparation Products And Raw materials |
| Raw materials | Morphinan-17-carboxylic acid, 4,5-epoxy-3-[(ethoxycarbonyl)oxy]-14-hydroxy-6-oxo-, ethyl ester, (5α)--->Morphinan-17-carboxylic acid, 7,8-didehydro-4,5-epoxy-6-hydroxy-3-methoxy-, ethyl ester, (5α,6α)--->(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride-->Morphinan-6-one, 17-acetyl-3-(acetyloxy)-4,5-epoxy-14-hydroxy-, (5α)--->6,11b-Ethano-7H-furo[2',3',4',5':4,5]phenanthro[9,8a-d]oxazol-11(11aH)-one, 2-(acetyloxy)-5,5a,9,10-tetrahydro-, (5aR,6R,8aS,11aR,11bS)--->(5alpha)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one-->(5alpha)-7,8-didehydro-4,5-epoxy-3,14-dihydroxymorphinan-6-one-->Naloxone | | Preparation Products | nalbuphine-->NALBUPHINE HYDROCHLORIDE-->hydromorphinol-->NALBUPHINE-->OXYMORPHONE-->Naltrexone hydrochloride |
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