4,4'-propylenebis(piperazine-2,6-dione)

4,4'-propylenebis(piperazine-2,6-dione) Basic information
Product Name:4,4'-propylenebis(piperazine-2,6-dione)
Synonyms:4,4'-propylenebis(piperazine-2,6-dione);4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione);RAZOXANUM;4,4'-(1-Methylethylene)bis(2,6-piperazinedione);4,4'-Propane-1,2-diyldipiperazine-2,6-dione;Propyliminum;4-[3-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;Troxozone
CAS:21416-67-1
MF:C11H16N4O4
MW:268.27
EINECS:244-379-2
Product Categories:Angiogenesis and metastasis.
Mol File:21416-67-1.mol
4,4'-propylenebis(piperazine-2,6-dione) Structure
4,4'-propylenebis(piperazine-2,6-dione) Chemical Properties
Melting point 237-239°
Boiling point 411.43°C (rough estimate)
density 1.2576 (rough estimate)
refractive index 1.6081 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility DMSO: soluble40mg/mL
form solid
pka11.00±0.20(Predicted)
Water Solubility 3g/L(25 ºC)
Safety Information
WGK Germany 3
RTECS TL6389900
MSDS Information
4,4'-propylenebis(piperazine-2,6-dione) Usage And Synthesis
UsesRazoxane is an inhibitor of Topo II.
DefinitionChEBI: Razoxane is a N-alkylpiperazine.
Safety ProfileSuspected human carcinogen producing leukemia and skin tumors. Moderately toxic by intraperitoneal route. Human effects: normocytic anemia and thrombocytopenia. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
4,4'-propylenebis(piperazine-2,6-dione) Preparation Products And Raw materials
Dexrazoxane polyethyleneimine Ethyl dimorpholine

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