mefruside

mefruside Basic information
Product Name:mefruside
Synonyms:1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]- (9CI);4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide;B 1500;BAY 1500;Baycaron;FBA 1500;FDA 1902;m-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)- (7CI, 8CI)
CAS:7195-27-9
MF:C13H19ClN2O5S2
MW:382.88
EINECS:2305624
Product Categories:
Mol File:7195-27-9.mol
mefruside Structure
mefruside Chemical Properties
Melting point 149.5°C
Boiling point 565.2±60.0 °C(Predicted)
density 1.3150 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.26±0.60(Predicted)
color White to Pale Beige
Stability:Hygroscopic
Safety Information
ToxicityLD50 oral in rabbit: > 3gm/kg
MSDS Information
mefruside Usage And Synthesis
OriginatorBaycaron,Bayer,W. Germany,1967
UsesMefruside is a diuretic used for the treatment of edema and hypertension.
DefinitionChEBI: Mefruside is an organic molecular entity.
Manufacturing ProcessBy hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol.
Therapeutic FunctionDiuretic
mefruside Preparation Products And Raw materials
Raw materialsDimethyl sulfate
Furfurylamine tetrahydrofurfuryl-2-methylamine CLOFENAMIDE mefruside 2-Methyltetrahydrofuran

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.