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| Product Name: | Triethyl citrate | | Synonyms: | 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, triethyl ester;1,2,3-Propanetricarboxylicacid,2-hydroxy-,triethylester;2,3-propanetricarboxylicacid,2-hydroxy-triethylester;2-Hydroxy-1,2,3-propanetricarboxylic acid, triethyl ester;2-hydroxy-propane-1,2,3-tricarboxylicacidtriethylester;Citroflex 2;citroflex2;Crodamol TC | | CAS: | 77-93-0 | | MF: | C12H20O7 | | MW: | 276.28 | | EINECS: | 201-070-7 | | Product Categories: | catalyst;Amino ester;Functional Materials;Hydroxycarboxylic Acid Esters (Plasticizer);Plasticizer;Pyridines;77-93-0;bc0001 | | Mol File: | 77-93-0.mol |  |
| | Triethyl citrate Chemical Properties |
| Melting point | -55 °C | | Boiling point | 235 °C/150 mmHg (lit.) | | density | 1.14 g/mL at 25 °C (lit.) | | vapor density | 9.7 (vs air) | | vapor pressure | 1 mm Hg ( 107 °C) | | FEMA | 3083 | TRIETHYL CITRATE | | refractive index | n20/D 1.442(lit.) | | Fp | >230 °F | | storage temp. | Store below +30°C. | | solubility | H2O: soluble | | form | Liquid | | pka | 11.57±0.29(Predicted) | | color | Clear | | Odor | odorless | | Water Solubility | 5.7 g/100 mL (25 ºC) | | FreezingPoint | -55℃ | | Merck | 14,2326 | | JECFA Number | 629 | | BRN | 1801199 | | InChIKey | DOOTYTYQINUNNV-UHFFFAOYSA-N | | LogP | 1.267 (est) | | CAS DataBase Reference | 77-93-0(CAS DataBase Reference) | | NIST Chemistry Reference | Ethyl citrate(77-93-0) | | EPA Substance Registry System | Triethyl citrate (77-93-0) |
| Hazard Codes | Xn | | Risk Statements | 20 | | Safety Statements | 24/25-45 | | WGK Germany | 1 | | RTECS | GE8050000 | | TSCA | Yes | | HS Code | 2918 15 00 | | Hazardous Substances Data | 77-93-0(Hazardous Substances Data) | | Toxicity | LD50 orally in Rabbit: > 3200 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
| | Triethyl citrate Usage And Synthesis |
| Toxicity |
AD10~20mg/kg (FAO/WHO, 2001). GRAS (FDA, §182.1911, 2000). LD505900 mg/kg (rat, oral).
| | Description | Triethyl citrate is the triester of citric acid and ethyl alcohol.
Triethyl citrate is used as a flavoring agent in foods, as a high boiling solvent and plasticizer for vinyl resins and cellulose acetates, as a plasticizer in the pharmaceutical industry for coating. Triethyl citrate is used as a natural active ingredient and flavor component with excellent deodorizing and skin care properties in cosmetic and personal care products. Triethyl citrate is also used as a plasticizer and humectant for cigarette filters. Furthermore, triethyl citrate is used s a food additive for stabilizing foams, specifically as a whipping enhancer for organic egg whites during processing.
| | References | [1] RH Dave (2016) Overview of pharmaceutical excipients used in tablets and capsules, Drug Topics (online). Advanstar.
[2] http://www.who.int/en/
[3] http://www.in-cosmetics.com
[4] http://www.chemicalland21.com
[5] https://www.ams.usda.gov/sites/default/files/media/Triethyl%20Citrate%20report%202014.pdf
| | Chemical Properties | Triethyl citrate is odorless, but has a bitter taste. | | Chemical Properties | Colorless, mobile liquid; bitter taste. Solubility
in water 6.5 g/100 cc; solubility in oil 0.8 g/100 cc.
Combustible. | | Chemical Properties | Triethyl citrate is a clear, viscous, odorless, and practically colorless,
hygroscopic liquid. | | Occurrence | Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white
wine. | | Uses | Triethyl Citrate, is a colorless, odorless liquid used as a food additive to stabilize foams, especially as whipping aid for egg white. It is also used in pharmaceutical coatings and plastics. This compound is a contaminant of emerging concern (CECs). | | Uses | Pharmaceutic aid (plasticizer). | | Uses | Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu-
ble in water. it is found in lemon drinks. | | Production Methods | Triethyl citrate is prepared by the esterification of citric acid and
ethanol in the presence of a catalyst. | | Preparation | By esterification of ethyl alcohol with citric acid. | | Definition | ChEBI: Triethyl citrate is a carbonyl compound. | | General Description | Triethyl citrate is a safe direct food additive. | | Pharmaceutical Applications | Triethyl citrate and the related esters acetyltriethyl citrate, tributyl
citrate, and acetyltributyl citrate are used to plasticize polymers in
formulated pharmaceutical coatings. The coating applications
include capsules, tablets, beads, and granules for taste masking,
immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring,
for solvency, and as a surface active agent. | | Safety Profile | Moderately toxic by
intraperitoneal route. Mildly toxic by
ingestion and inhalation. Combustible liquid
when exposed to heat or flame. To fight
fire, use dry chemical, CO2. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ESTERS and
CITRIC ACID. | | Safety | Triethyl citrate is used in oral pharmaceutical formulations and as a
direct food additive. It is generally regarded as a nontoxic and
nonirritant material. However, ingestion of large quantities may be
harmful.
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg | | storage | Triethyl citrate should be stored in a closed container in a cool, dry
location. When stored in accordance with these conditions, triethyl
citrate is a stable product. | | Incompatibilities | Triethyl citrate is incompatible with strong alkalis and oxidizing
materials. | | Regulatory Status | GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal
Ingredients. |
| | Triethyl citrate Preparation Products And Raw materials |
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