| Chemical Properties | white to cream fine crystalline powder |
| Uses | Reagent used in the preparation of Antithyroid agents. |
| Uses | antiviral, thyroid depressant |
| Uses | 2-Thiouracil has been used in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS) |
| Definition | ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group. |
| Biochem/physiol Actions | 2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase. It acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), Chromium (Cr), Zinc (Zn), and Silver (Ag). |
| Safety Profile | Moderately toxic by
ingestion. Human teratogenic effects by
unspecified routes: developmental
abnormalities of the central nervous system,
craniofacial area, and endocrine system.
Human reproductive effects by unspecified
route: effects on newborn, including viabllity
index changes. Experimental teratogenic
effects. Other experimental reproductive
effects. Questionable carcinogen with
experimental neoplastigenic and tumorigenic
data. Mutation data reported. When heated
to decomposition it emits very toxic fumes
of NOx and SOx. Used in the treatment of
hyperthyroidism, angina pectoris, and
congestive heart failure. See also
MERCAPTANS and KETONES. |
| Purification Methods | Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.] |
