20-HETE

20-HETE Basic information
Product Name:20-HETE
Synonyms:20-HETE, 20-Hydroxyarachidonic acid;20-HETE Lipid Maps MS Standard;20-Hydroxyeicosa-5Z,8Z,11Z,14Z-tetraenoic acid;20-HYDROXY-(5Z,8Z,11Z,14Z)-EICOSATETRAENOIC ACID;20-HYDROXYARACHIDONIC ACID;20-HETE;20-Hydroxyarachlidonic acid;(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid
CAS:79551-86-3
MF:C20H32O3
MW:320.47
EINECS:
Product Categories:
Mol File:79551-86-3.mol
20-HETE Structure
20-HETE Chemical Properties
Boiling point 482.0±33.0 °C(Predicted)
density 0.985±0.06 g/cm3(Predicted)
Fp 14℃
storage temp. -20°C
solubility 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form Powder
pka4.75±0.10(Predicted)
Safety Information
Hazard Codes F,Xi
Risk Statements 11-36/37/38
Safety Statements 16-26-36
RIDADR UN 1170 3/PG 2
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
20-HETE Usage And Synthesis
Uses20-HETE is a cytochrome P450 (CYP450) metabolite that may play an autacoid role in cerebral and renal vasculature.
DefinitionChEBI: A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 20.
Biochem/physiol Actions20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats.
20-HETE Preparation Products And Raw materials
20-HETE-D6 ARACHIDONYL ALCOHOL APPROX 99 20-HETE Arachidonic acid

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