5-Chlorosalicylaldehyde

5-Chlorosalicylaldehyde Basic information
Product Name:5-Chlorosalicylaldehyde
Synonyms:5-CHLOROSALICYLALDEHYDE;5-Chlorosalicylic aldehyde;5-CHLORO-2-HYDROXYBENZALDEHYDE;2-HYDROXY-5-CHLOROBENZALDEHYDE;AKOS 90774;5-Chlorosalicyladehyde;5-Cl-salicylal;5-Chloro-2-Hydroxybenzaldehyde (5-Chlorosalicylaldehyde)
CAS:635-93-8
MF:C7H5ClO2
MW:156.57
EINECS:211-244-4
Product Categories:Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Adehydes, Acetals & Ketones;Chlorine Compounds;Phenols;Aldehydes;FINE Chemical & INTERMEDIATES;Alcohols and Derivatives;Carbonyl Compounds;C7;Carbonyl Compounds;bc0001
Mol File:635-93-8.mol
5-Chlorosalicylaldehyde Structure
5-Chlorosalicylaldehyde Chemical Properties
Melting point 100-102 °C(lit.)
Boiling point 217.69°C (rough estimate)
density 1.2683 (rough estimate)
refractive index 1.5812 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka7.73±0.18(Predicted)
form Crystalline Powder
color White to very slightly yellow
Sensitive Air Sensitive
BRN 636632
LogP2.570 (est)
CAS DataBase Reference635-93-8(CAS DataBase Reference)
NIST Chemistry Reference5-Chloro-2-hydroxy benzaldehyde(635-93-8)
EPA Substance Registry SystemBenzaldehyde, 5-chloro-2-hydroxy- (635-93-8)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36-24/25-36/37/39
RIDADR UN2811/6.1/PG III
WGK Germany 3
RTECS VN5450000
Hazard Note Irritant
TSCA Yes
HS Code 29130000
MSDS Information
ProviderLanguage
5-Chlorosalicylic aldehyde English
SigmaAldrich English
ACROS English
ALFA English
5-Chlorosalicylaldehyde Usage And Synthesis
Chemical Propertieswhite to very slightly yellow crystalline powder
Uses5-Chlorosalicyaldehyde is a useful synthetic intermediate and a key precursor to a variety chelating agents.5-Chlorosalicyaldehyde is used to synthesize imine resveratrol (R150000) derivatives as multi-targeted agents against Alzheimer's disease.
Synthesis Reference(s)Synthetic Communications, 20, p. 609, 1990 DOI: 10.1080/00397919008244911
Tetrahedron Letters, 15, p. 3463, 1974
Purification MethodsSteam distil it, then crystallise it from aqueous EtOH or *C6H6 (m 100o). It forms complexes with Cu2+ and Fe2+ . [Beilstein 8 H 53, 8 II 45, 8 III 181, 8 IV 224.]
1-Chloro-2-methylpropane 3-Chloropivaloyl chloride 6-CHLOROCHROMAN-4-ONE 1-Nonanal Paraldehyde Chlorocyclohexane Difluorochloromethane 5-Chlorosalicylaldehyde 3-BROMO-5-CHLOROSALICYLALDEHYDE Salicylaldehyde METHYL 5-CHLORO-2-METHOXYBENZOATE 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID N-Chlorosuccinimide 5-Chloro-2-hydroxybenzoic acid 2-Ethoxy-4-amino-5-chlorobenzoic acid Methyl 5-chloro-2-hydroxybenzoate 6,8-DICHLORO-3-FORMYLCHROMONE 5-Chloro-2-methoxybenzoic acid

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