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| | Isosilybin Basic information |
| Product Name: | Isosilybin | | Synonyms: | ISOSILIBININ;ISOSILYBIN(PRIMARY STANDARD);Isosilybinin;Isosilybin (Isosilybinin);(2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;ISOSILYBIN hplc;Isosilybin (A+B) mixture;-(2,3-Dihydro-2-(4-hydroxy-3-Methoxyphenyl)-3-(hydroxyMethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one | | CAS: | 72581-71-6 | | MF: | C25H22O10 | | MW: | 482.44 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;Miscellaneous Natural Products;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 72581-71-6.mol |  |
| | Isosilybin Chemical Properties |
| Boiling point | 793.0±60.0 °C(Predicted) | | density | 1.527±0.06 g/cm3(Predicted) | | storage temp. | Store at -20° C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.1 mg/ml | | form | Solid | | pka | 7.39±0.60(Predicted) | | color | White-light yellow |
| | Isosilybin Usage And Synthesis |
| Description | Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice. | | Uses | Useful in the treatment of liver disease. | | Uses | Isosilybin is useful in the treatment of liver disease
| | Definition | ChEBI: A flavonolignan isolated from Silybum marianum. |
| | Isosilybin Preparation Products And Raw materials |
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