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| | Ethoxyquin Basic information |
| Product Name: | Ethoxyquin | | Synonyms: | 1,2-dihydro-2,2,4-trimethyl-6-ethoxyquinoline;2,2,4-trimethyl-6-ethoxy-1,2-dihydroquinoline;6-ethoxy-1,2-dihydro-2,2,4-trimethyl-quinolin;6-Ethoxyl-2,2,4-trimethyl-1,2-dihydrquinoline;amea100;antageaw;AntioxidantAW;antioxidantec | | CAS: | 91-53-2 | | MF: | C14H19NO | | MW: | 217.31 | | EINECS: | 202-075-7 | | Product Categories: | C11 to C30;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Quinolines;Amines;Aromatics;Heterocycles;Antioxidant;Biochemistry;Industrial/Fine Chemicals;INORGANIC & ORGANIC CHEMICALS;91-53-2 | | Mol File: | 91-53-2.mol |  |
| | Ethoxyquin Chemical Properties |
| Melting point | <0°C | | Boiling point | 123-125°C | | density | 1.03 g/mL at 20 °C (lit.) | | vapor pressure | 0.035Pa at 25℃ | | refractive index | 1.569~1.571 | | Fp | 137 °C | | storage temp. | 2-8°C | | solubility | ethanol: 50 mL/L, clear, brown | | pka | 5.02±0.70(Predicted) | | form | neat | | color | Yellow to Very Dark Brown | | Water Solubility | <0.1 g/100 mL at 20 ºC | | Merck | 14,3753 | | BRN | 158223 | | Stability: | Stable. Combustible. Incompatible with oxidizing agents, strong acids. Polymerizes if heated. May polymerize upon exposure to light and air. | | InChIKey | DECIPOUIJURFOJ-UHFFFAOYSA-N | | LogP | 3.39 | | CAS DataBase Reference | 91-53-2(CAS DataBase Reference) | | NIST Chemistry Reference | Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-(91-53-2) | | EPA Substance Registry System | Ethoxyquin (91-53-2) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 24 | | RIDADR | 3082 | | WGK Germany | 1 | | RTECS | VB8225000 | | F | 2-8-10 | | HazardClass | 9 | | PackingGroup | III | | HS Code | 29334900 | | Hazardous Substances Data | 91-53-2(Hazardous Substances Data) | | Toxicity | LD50 orally in rats, mice: 1920, 1730 mg/kg (Piul'skaya) |
| | Ethoxyquin Usage And Synthesis |
| Description | Ethoxyquin is used as an antioxidant in animal feed
and caused contact dermatitis in a worker at an animal
feed mill. | | Chemical Properties | Transparent yellow or brown viscous liquid. Discolors and stains badly. Soluble in benzene, gasoline, ether, ethanol, carbon tetrachloride, acetone, dichloroethane, insoluble in water. | | Uses | Antioxidant in feed and food; antidegradation agent for rubber. | | Uses | Ethoxyquin is an antioxidant used in the preservation of color in
chili powder, ground chili, and paprika. | | Definition | ChEBI: Ethoxyquin is a quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6. It has a role as a herbicide, an UDP-glucuronosyltransferase activator, a neuroprotective agent, a Hsp90 inhibitor, a genotoxin, a food antioxidant, a geroprotector and an antifungal agrochemical. It is a member of quinolines and an aromatic ether. | | General Description | Clear light yellow to dark brown viscous liquid. Discolors and stains badly. Mercaptan-like odor. | | Air & Water Reactions | Polymerizes and darkens in color on exposure to light and air. Insoluble in water. | | Reactivity Profile | Ethoxyquin may undergo a hazardous polymerization at temperatures above 320° F. Tends to polymerize and darken in color on exposure to light and air. Not compatible with oxidizing agents and with strong acids . | | Hazard | Toxic by ingestion. | | Fire Hazard | Ethoxyquin is combustible. | | Agricultural Uses | Insecticide, Fungicide, Plant growth regulator,
Ingredient in other products: Used for preharvest or postharvest preservation of
color in apples and pears. It is used as an antioxidant to
preserve color in paprika and ground and powdered chili.
Ethoxyquin is also a chemical preservative used in animal
feed to prevent ingredients from reacting with oxygen and
becoming rancid. It has been known to cause birth defects
in pet birds and dogs. Not approved for use in EU countries[
115]. Registered for use in the U.S. | | Trade name | CHEMLEY®[C]; DECCOQUIN
305®; EMQ®; EQ®; NIFLEX®; NIX-SCALD®[C];
SANTOFLEX A®; SANTOFLEX AW®; SANTOQUIN®;
SANTOQUINE®; STOP-SCALD® | | Contact allergens | Ethoxyquin is used as an antioxidant in animal feed
and caused contact dermatitis in a worker at an animal
feed mill | | Safety Profile | Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. | | Potential Exposure | Quinoline insecticide, fungicide and
plant growth regulator. Also and ingredient in other products. Used for preharvest or postharvest preservation of
color in apples and pears. It is used as an anti-oxidant to
preserve color in paprika and ground and powdered chili.
Ethoxyquin also is a chemical preservative used in animal
feed to prevent ingredients from reacting with oxygen and
becoming rancid. It has been known to cause birth defects
in pet birds and dogs | | Shipping | UN3082 Environmentally hazardous substances,
liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required | | Purification Methods | Purify Ethoxyquin by fractional distillation in vacuo whereby the distillate solidifies to a glass. [Knoevenagel Chem Ber 54 1723, 1730 1921.] The methiodide has m 179o (from EtOH), and the 1-phenylcarbamoyl derivative has m 146-147o (from EtOH). [Beaver et al. J Am Chem Soc 79 1236 1957, Beilstein 21 III/IV 95.] | | Incompatibilities | Polymerization can occur on contact
with strong light and/or water. Decomposes in temperatures
above 150℃. Keep away from oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); strong acids. | | Waste Disposal | Do not discharge into drains
or sewers. Dispose of waste material as hazardous waste
using a licensed disposal contractor to an approved landfill.
Consult with environmental regulatory agencies for
guidance on acceptable disposal practices. If allowed,
Incineration with effluent gas scrubbing is recommended.
Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your
regional EPA office |
| | Ethoxyquin Preparation Products And Raw materials |
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