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| | 1,4-PHENYLENE DIISOTHIOCYANATE Basic information |
| Product Name: | 1,4-PHENYLENE DIISOTHIOCYANATE | | Synonyms: | 1,4-diisothiocyanato-benzen;1,4-diisothiocyanatobenzene[qr];1,4-phenylenedi-isothiocyanicaci;Phenylene-1,4-diisothiocyanate, 1,4-Diisothiocyanatobenzene;PDITC;p-Phenylene diisothiocyanate 98%;p-Phenylene diisothiocyanate(PDITC);1,4-Phenylene diisothiocyanate for synthesis | | CAS: | 4044-65-9 | | MF: | C8H4N2S2 | | MW: | 192.26 | | EINECS: | 223-741-3 | | Product Categories: | reagent;JONIT | | Mol File: | 4044-65-9.mol |  |
| | 1,4-PHENYLENE DIISOTHIOCYANATE Chemical Properties |
| Melting point | 129-131 °C (lit.) | | Boiling point | 339.4±25.0 °C(Predicted) | | density | 1.3675 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | −20°C | | solubility | chloroform: clear | | form | powder | | color | white | | Water Solubility | Hydrolyzes in water. | | Sensitive | Moisture Sensitive | | Merck | 14,1308 | | BRN | 2414340 | | InChIKey | OMWQUXGVXQELIX-UHFFFAOYSA-N | | CAS DataBase Reference | 4044-65-9(CAS DataBase Reference) | | EPA Substance Registry System | Bitoscanate (4044-65-9) |
| | 1,4-PHENYLENE DIISOTHIOCYANATE Usage And Synthesis |
| Chemical Properties | Those engaged in the manufacture,
formulation and application of this anthelmintic
compound.
Incompatibilities: In general, keep away from strong oxidizers,
moisture, strong acids, strong bases. This is a thiocyanate
compound. Violent reactions may occur upon contact
with chlorates (potassium chlorate, sodium chlorate),
nitrates, nitric acid; organic peroxides. | | Chemical Properties | off-white to yellow to beige-grey crystalline | | Uses | It is used in the treatment of?hookworms. | | Uses | anthelmintic | | Uses | Reagent for solid-phase sequencing. | | Definition | ChEBI: Bitoscanate is a member of benzenes. | | General Description | Odorless colorless crystals. Melting point 132°C. | | Reactivity Profile | 1,4-PHENYLENE DIISOTHIOCYANATE reacts readily with amines [Noller]. These reactions may generate significant amounts of heat . Emits very toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition [EPA, 1998]. | | Health Hazard | 1,4-PHENYLENE DIISOTHIOCYANATE is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans. | | Fire Hazard | When heated to decomposition, 1,4-PHENYLENE DIISOTHIOCYANATE emits very toxic fumes of nitrogen oxides and sulfur oxides. | | Safety Profile | Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, nausea. When heated to decomposition it emits very toxic fumes of NOx,CN,and SOx.See also THIOCYANATES | | Potential Exposure | Those engaged in the manufacture,
formulation and application of this anthelmintic
compound.
Incompatibilities: In general, keep away from strong oxidizers,
moisture, strong acids, strong bases. This is a thiocyanate
compound. Violent reactions may occur upon contact
with chlorates (potassium chlorate, sodium chlorate),
nitrates, nitric acid; organic peroxides. | | Shipping | UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1—Poisonous materials, Technical
Name Required. | | Purification Methods | Purify bitoscanate by recrystallisation from AcOH, pet ether (b 40-60o), Me2CO or aqueous Me2CO. [van der Kerk et al. Recl Trav Chim Pays-Bas 74 1262 1955, Leiber & Slutkin J Org Chem 27 2214 1962, Beilstein 13 IV 174.] | | Incompatibilities | Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. |
| | 1,4-PHENYLENE DIISOTHIOCYANATE Preparation Products And Raw materials |
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