Glycine ethyl ester hydrochloride

Glycine ethyl ester hydrochloride Basic information

Product Name:	Glycine ethyl ester hydrochloride
Synonyms:	Glycineethylesterhydrochlor;Glycocollethylesterhydrochloride;usafdo-10;glycine ethyhydnchlordeester;Glycineethylester·HCl,Glycineethylesterhydrochloride;Ethyl 2-aminoacetate, hydrochloride;Glycine ethyl ester hydrochloride ,98%;2-Aminoacetic acid ethyl·hydrochloride
CAS:	623-33-6
MF:	C4H9NO2.ClH
MW:	139.58
EINECS:	210-787-4
Product Categories:	Amino Acids;Amino Acid Derivatives;Food and Feed Additive;Amino Acids & Derivatives;Glycine [Gly, G];Amino Acids and Derivatives;Amino Acid Ethyl Esters;Amino Acids (C-Protected);Biochemistry;Amino hydrochloride;Pharmaceutical intermediates;bc0001;623-33-6
Mol File:	623-33-6.mol

Glycine ethyl ester hydrochloride Chemical Properties

Melting point	145-146 °C(lit.)
density	1.371 g/cm3
storage temp.	2-8°C
solubility	>1000 g/L (20 °C)
pka	pK1:7.66(＋1) (25°C)
form	Crystalline Powder
color	White
PH	2.9 (10g/l, H2O, 20℃)
Odor	Odorless
Water Solubility	>1000 g/L (20 ºC)
Sensitive	Hygroscopic
BRN	3594034
InChIKey	TXTWXQXDMWILOF-UHFFFAOYSA-N
CAS DataBase Reference	623-33-6(CAS DataBase Reference)
EPA Substance Registry System	Glycine, ethyl ester, hydrochloride (623-33-6)

Safety Information

Hazard Codes	Xi
Risk Statements	41-36/37/38
Safety Statements	26-39-24/25-37/39
WGK Germany	3
RTECS	MC0525000
TSCA	Yes
HS Code	29224995

MSDS Information

Provider	Language
Ethyl glycinate hydrochloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

Glycine ethyl ester hydrochloride Usage And Synthesis

Chemical Properties	Crystalline
Uses	Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.
Uses	As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin.
Synthesis	A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.
Purification Methods	Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.]

Glycine ethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol-->Hydrochloric acid-->Hydrogen-->Glycine-->Hexamethylenetetramine-->Hydrochloric acid alcohol

Preparation Products

3-BROMO-6-METHYL-2-OXO-1(2H)-PYRAZINEACETIC ACID ETHYL ESTER-->4-BOC-AMINOMETHYL-1-N-BOC-PYRROLIDIN-3-OL-->1-(Boc-amino)cyclopropanecarboxylic acid-->4,5,6,7-TETRAHYDRO-2-METHYLFURO[2,3-C]PYRIDINE-->tert-butyl 3-(aminomethyl)-4-hydroxypyrrolidine-1-carboxylate-->ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate-->1-Aminocyclopropanecarboxylic acid-->4-Imidazolemethanol hydrochloride-->H-GLY-AMC HBR-->ethyl 2-(3,4-dihydro-6-methyl-2,3-dioxopyrazin-1(2H)-yl)acetate-->ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate-->N-Boc-3-cyano-4-hydroxypyrrolidine-->Tetramethrin-->Ethyl imidazole-4-carboxylate-->Glycine methyl ester hydrochloride-->2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester-->Anagrelide-->ETHYL 2-[(2-THIENYLCARBONYL)AMINO]ACETATE-->Ethyl diazoacetate-->Ethyl N-(diphenylmethylene)glycinate-->N-FORMYLGLYCINE ETHYL ESTER-->N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER

H-GLY-PHE-GLY-OH GLYCYL-L-PHENYLALANINE H-GLY-PHE-PNA HCL GLYCYL-SARCOSINE Benzyl glycinate p-toluenesulfonate N-[2-(BOC-AMINO)ETHYL]GLYCINE ETHYL ESTER HYDROCHLORIDE GLYCINE ETHYL ESTER HYDROCHLORIDE, [GLYCINE 1-14C] GLYCINE ETHYL ESTER HYDROCHLORIDE, [GLYCINE 2-14C] Benzylaminoacetic acid hydrochloride Topotecan hydrochloride Creatine ethyl ester hydrochloride GlycineMax GLYCINE ETHYL ESTER HYDROCHLORIDE extrapure Ethyl L-methionate hydrochloride N-(4-CHLORO-PHENYL)-OXALAMIC ACID ETHYL ESTER Diethyl L-glutamate hydrochloride D-(-)-ALPHA-PHENYLGLYCINE ETHYL ESTER HYDROCHLORIDE 7-Amino-heptanoic acid ethyl ester hydrochloride

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Glycine ethyl ester hydrochloride

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