ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards (3S,5R)-Rosuvastatin

(3S,5R)-Rosuvastatin

(3S,5R)-Rosuvastatin Basic information
Product Name:(3S,5R)-Rosuvastatin
Synonyms:(3S,5R)-Rosuvastatin;(3s,5r,6e)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid;Rosuvastatin EP Impurity G;Rosuvastatin (3S,5R) Enantiomer (as diisopropylamine salt);(3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;Rosuvastatin (3S,5R) enantiomer;(3S,5R,6E)-Rosuvastatin;(3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid, calcium salt (2:1)
CAS:1242184-42-4
MF:C22H28FN3O6S
MW:481.54
EINECS:
Product Categories:
Mol File:1242184-42-4.mol
(3S,5R)-Rosuvastatin Structure
(3S,5R)-Rosuvastatin Chemical Properties
Boiling point 745.6±70.0 °C(Predicted)
density 1.368±0.06 g/cm3(Predicted)
solubility soluble in Methanol, Water
pka4.25±0.10(Predicted)
form Solid
color Off-White to Pale Yellow
Stability:Hygroscopic
Safety Information
MSDS Information
(3S,5R)-Rosuvastatin Usage And Synthesis
DescriptionRosuvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Uses(3S,5R,6E)-Rosuvastatin is an isomer of Rosuvastatin(R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor.
Biological Activity(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
(3S,5R)-Rosuvastatin Preparation Products And Raw materials
Rosuvastatin Impurity 4 Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt) Rosuvastatin EP impurity H 3-Oxo Rosuvastatin SodiuM Salt 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide Rosuvastatin EP impurity A Rosuvastatin IsoaMy Ester Rosuvastatin Anhydro Lactone Rosuvastatin IMpurity (5-Oxo Rosuvastatin tert-Butyl Ester) (3S,5R)-Rosuvastatin Methyl Ester N-DESMETHYL ROSUVASTATIN-D3 (3R,5R)-Rosuvastatin Rosuvastatin Impurity 14 (3R,5S,Z)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid calcium(II) Rosuvastatin Impurity 22 Methanesulfonamide, N-[5-ethenyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.