2-Amino-4-bromo-3-fluorobenzoic acid

2-Amino-4-bromo-3-fluorobenzoic acid Basic information

Product Name:	2-Amino-4-bromo-3-fluorobenzoic acid
Synonyms:	2-Amino-4-bromo-3-fluorobenzoic acid;3-BROMO-6-CARBOXY-2-FLUOROANILINE;140622;Benzoic acid, 2-amino-4-bromo-3-fluoro-;Ethanol,5-diazenyl-;2-amino-4-bromo-3-fluorobenzoicaci;Oxymetazoline Impurity 10;2-Amino-3-fluoro-4-bromobenzoic acid
CAS:	1416013-62-1
MF:	C7H5BrFNO2
MW:	234.02
EINECS:
Product Categories:
Mol File:	1416013-62-1.mol

2-Amino-4-bromo-3-fluorobenzoic acid Chemical Properties

Boiling point	332.0±42.0 °C(Predicted)
density	1.877±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	4.37±0.10(Predicted)
form	powder
color	Off white

Safety Information

HS Code

2922498590

MSDS Information

2-Amino-4-bromo-3-fluorobenzoic acid Usage And Synthesis

Uses

2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents.

Synthesis

The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid.png

2-Amino-4-bromo-3-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

6-bromo-7-fluoroisatin-->4-BROMO-2,3-DIFLUOROBENZOIC ACID

2-Amino-5-bromopyrazine 2-Amino-6-bromopyridine 2-Amino-4-bromopyridine 3-METHOXY-2-AMINOBENZAMIDE no

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2-Amino-4-bromo-3-fluorobenzoic acid

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