≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH
form
solid
pka
3.67±0.10(Predicted)
Safety Information
MSDS Information
VX-222 Usage And Synthesis
Description
Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).
Uses
VX-222, s a novel, potent and selective inhibitor of HCV polymerase .
Definition
ChEBI: 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-[(4-methylcyclohexyl)-oxomethyl]amino]-2-thiophenecarboxylic acid is a thiophenecarboxylic acid.
