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| | methyl 3-bromo-4-methyl-5-nitropicolinate Basic information |
| Product Name: | methyl 3-bromo-4-methyl-5-nitropicolinate | | Synonyms: | methyl 3-bromo-4-methyl-5-nitropicolinate;2-Pyridinecarboxylic acid, 3-bromo-4-methyl-5-nitro-, methyl ester;3-Bromo-4-methyl-5-nitro-2-pyridinecarboxylic acid methyl ester;methyl3-bromo-4-methyl-5-nitropyridine-2-carboxylate;methyl 3-bromo-4-methyl-5-nitropicolinate ISO 9001：2015 REACH | | CAS: | 1150618-07-7 | | MF: | C8H7BrN2O4 | | MW: | 275.06 | | EINECS: | 200-589-5 | | Product Categories: | | | Mol File: | 1150618-07-7.mol |  |
| | methyl 3-bromo-4-methyl-5-nitropicolinate Chemical Properties |
| Boiling point | 377.2±42.0 °C(Predicted) | | density | 1.668 | | storage temp. | 2-8°C | | pka | -4.11±0.10(Predicted) |
| | methyl 3-bromo-4-methyl-5-nitropicolinate Usage And Synthesis |
| Preparation | Methyl-3-bromo-4-methyl-5-nitropicolinate synthesis: 3-bromo-2-iodo-4-methyl-5-nitropyridine (129.0 g, 0.38 mol) and (Ph3P)2PdCl2 (7.92 g, 3 mol%) were suspended in CH3CN (1300 mL) and MeOH (430 mL) and Et3N (79.3 mL, 1.5 eq) was added. The mixture was transferred to a steel 5000 mL pressure vessel, 4 bar of CO pressure was applied and the reaction mixture was slowly heated to 80 oC. Subsequently, it was stirred for 5 h at this temperature, then allowed to cool overnight. The volatiles were removed in vacuo, the residue was stirred in EtOAc (1000 mL) and filtered. The residue was extracted with EtOAc (2*250 mL) and the combined filtrates were washed with brine (1000 mL) and dried on Na2SO4. The volatiles were removed in vacuo, affording 120 g of a brown oil. This was coated on 120 g of silicagel and purified by column chromatography (3500 g of silica gel, EtOAc/heptane 1:3, KMnO4 staining). The appropriate fractions were combined and concentrated to give Methyl-3-bromo-4-methyl-5-nitropicolinate as a beige solid (63.5 g, 61%). |
| | methyl 3-bromo-4-methyl-5-nitropicolinate Preparation Products And Raw materials |
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