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| | Propyphenazone Basic information |
| Product Name: | Propyphenazone | | Synonyms: | 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on;3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-;4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on;4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;4-Isopropyl-2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline;4-isopropyl-antipyrin | | CAS: | 479-92-5 | | MF: | C14H18N2O | | MW: | 230.31 | | EINECS: | 207-539-2 | | Product Categories: | Aromatics;Heterocycles;Active Pharmaceutical Ingredients;API's;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 479-92-5.mol |  |
| | Propyphenazone Chemical Properties |
| | Propyphenazone Usage And Synthesis |
| Description | This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known. | | Chemical Properties | solid | | Uses | Analgesic; antipyretic; anti-inflammatory. | | Definition | ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group. | | Brand name | 539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin. | | World Health Organization (WHO) | Propyphenazone, a pyrazolone derivative with anti-inflammatory,
analgesic and antipyretic activity, was introduced in 1951 for the treatment of
rheumatic disorders. As it is structurally related to aminophenazone it has been
associated with severe blood dyscrasias. However, it cannot be transformed into
potentially carcinogenic nitrosamines and has therefore been widely used as a
replacement drug for aminophenazone. In certain countries, products containing
propyphenazone have now been restricted in their indications, whereas in others
they are still available, sometimes as over-the-counter preparations. See also WHO
comment for aminophenazone. | | References | Hartsen., J. Chem. Soc., 511 (1873)
Mirande., Compt. rend., 168,316 (1919) |
| | Propyphenazone Preparation Products And Raw materials |
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