3-Aminopyridine

3-Aminopyridine Basic information

Product Name:	3-Aminopyridine
Synonyms:	3-amino-pyridin;3-Aminopyridine ,98%;3-mydroxypiperidine;3-aMatopyridate;NSC 15040;Pyridine, 3-aMino- (8CI);AMINOPYRIDINE, 3-(RG);462-08-0
CAS:	462-08-8
MF:	C5H6N2
MW:	94.11
EINECS:	207-322-2
Product Categories:	Building Blocks;C5;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;Pharmaceutical intermediates;FINE Chemical & INTERMEDIATES;Pyridine;Organics;Pyridine series;Pyridines derivates
Mol File:	462-08-8.mol

3-Aminopyridine Chemical Properties

Melting point	60-63 °C(lit.)
Boiling point	248 °C(lit.)
density	1.0308 (estimate)
refractive index	1.5560 (estimate)
Fp	124 °C
storage temp.	Poison room
solubility	>1000g/l
form	Liquid
pka	6.04(at 25℃)
color	Clear colorless to yellow
PH	10 (100g/l, H2O, 20℃)
Water Solubility	It is soluble in water as well as soluble in alcohol, benzene.
Sensitive	Air Sensitive & Hygroscopic
Merck	14,473
BRN	105692
InChIKey	CUYKNJBYIJFRCU-UHFFFAOYSA-N
LogP	0.110
CAS DataBase Reference	462-08-8(CAS DataBase Reference)
NIST Chemistry Reference	3-Pyridinamine(462-08-8)
EPA Substance Registry System	3-Aminopyridine (462-08-8)

Safety Information

MSDS Information

3-Aminopyridine Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	3-Aminopyridine is a monosubstituted pyridine that shows convulsive effects on cortical Neurons. 3-Aminopyridine is used in the synthesis of of organic ligand 3-Pyridylnicotinamide. 3-Aminopyridine al ong with other aminopyridines have been shown to reversibly block voltage-dependent potassium channels,
Uses	manufacture of pharmaceuticals and dyes.
Uses	3-Aminopyrodine is also used as an intermediate for agrochemicals, pharmaceuticals and colorants. These are involved in photosensitizer chemistry, luminescent materials, metal complex chemistry and liquid crystal. Aminopyridine is used as a monomer for polymerization. It is also used in the Production of cationic dyes and Apa amoxicillin sodium raw materials.
Synthesis Reference(s)	Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2 The Journal of Organic Chemistry, 57, p. 5254, 1992 DOI: 10.1021/jo00045a047
Safety Profile	Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx,.
Purification Methods	It crystallises from benzene, CHCl3/pet ether (b 60-70o), or benzene/pet ether (4:1). [Beilstein 22/9 V 3.]

3-Aminopyridine Preparation Products And Raw materials

Raw materials	Potassium hydroxide-->tert-Butanol-->Aluminum oxide-->Nicotinamide-->Lead tetraacetate-->3-Piperidinamine, 6-chloro--->Sulfuric acid-->2-Chloro-5-nitropyridine-->5-Amino-2-chloropyridine-->5-Amino-2-bromopyridine
Preparation Products	3-IODO-2-NITROPYRIDINE-->6-BROMO-2-METHOXY-PYRIDIN-3-YLAMINE-->N-(4-FORMYL-PYRIDIN-3-YL)-2,2-DIMETHYL-PROPIONAMIDE-->TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE-->Pirenzepine-->2,6-Dichloropyridin-3-amine-->3-HYDRAZINOPYRIDINE Dihydrochloride-->3-Iodopyridine-->2,6-Dibromopyridin-3-amine-->1,5-NAPHTHYRIDINE-2-CARBOXYLICACID -->2-Chloro-3-fluoropyridine-->2,6-Dibromopyridine

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