Amodiaquin dihydrochloride dihydrate Usage And Synthesis
Chemical Properties
Light yellow powder
Uses
An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor
Uses
antimalarial
Brand name
Camoquin (Parke-Davis).
Biological Activity
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
in vivo
In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.
Amodiaquin dihydrochloride dihydrate Preparation Products And Raw materials
