5-METHYLCYTOSINE

5-METHYLCYTOSINE Basic information

Product Name:	5-METHYLCYTOSINE
Synonyms:	4-Amino-5-methyl-2-pyrimidinol;Cytosine, 5-methyl-;5-Methylcytosine,>96%;2(1H)-Pyrimidinone, 4-amino-5-methyl- (9CI);4-amino-5-methyl-3H-pyrimidin-2-one;5-METHYLCYTOSINE;2(1H)-Pyrimidinone, 6-amino-5-methyl-;2(1H)-Oxo-4(3H)-imino-5-methylpyrimidine
CAS:	554-01-8
MF:	C5H7N3O
MW:	125.13
EINECS:	209-058-3
Product Categories:	Nucleic acids;Pyrimidines;PYRIMIDINE;Elisa Kit-Rat Elisa Kit
Mol File:	554-01-8.mol

5-METHYLCYTOSINE Chemical Properties

Melting point	270°C (rough estimate)
Boiling point	232.57°C (rough estimate)
density	1.2602 (rough estimate)
refractive index	1.6510 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Methanol (Sparingly, Heated)
form	Crystalline
pka	9.05±0.10(Predicted)
color	White to Off-White
Water Solubility	Soluble in water.
Merck	14,6050
CAS DataBase Reference	554-01-8(CAS DataBase Reference)

Safety Information

RTECS

UW7362350

MSDS Information

Provider	Language
ALFA	English

5-METHYLCYTOSINE Usage And Synthesis

Chemical Properties	Crystals in prisms from water.
Uses	5-Methylcytosine is used as a marker to protect DNA from being cut by native methylation-sensitive restriction enzymes. It is also employed in the production of 4-amino-5-hydroxy-5-methyl-2-oxo-2,5-dihydro-imidazole-1-carbaldehyde.
Definition	ChEBI: A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.
Purification Methods	Crystallise it from water (solubility is 3.4%). The hydrochloride has m 299-301o (sintering at 280o) (from aqueous HCl/Me2CO). [Hitchings et al. J Biol Chem 177 537 1949, Cohn J Am Chem Soc 73 1539 1951, Beilstein 25 II 183, 25 III/IV 3727.]

5-METHYLCYTOSINE Preparation Products And Raw materials

Raw materials

5-METHYL-2-THIOCYTOSINE-->5-methyl-4-(1,2,4-triazol-1-yl)-pyrimidin-2-(1H)-one-->2-(Ethylthio)-5-methyl-4-pyrimidinamine-->2(1H)-Pyrimidinone, 4-methoxy-5-methyl- (8CI,9CI)-->4-chloro-2-ethylsulfanyl-5-methyl-pyrimidine-->5-Methyl-2'-deoxycytidine-->5-HydroxyMethyl cytidine-->5-Hydroxy methyl-2’-deoxycytidine-->5-HYDROXYMETHYLCYTOSINE-->(5-methyl)dithiouracil-->5-formyl-2'-deoxycytidine-->5-METHYLCYTIDINE-->Ethanol-->Thymine

Preparation Products

1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

N4-BENZOYL-5-METHYLDEOXYCYTIDINE LISSAMINE-5-DCTP FLUORESCEIN-12-DCTP EOSIN-6-DDCTP 1-(2-Deoxy-beta-D-ribofuranosyl)-5-methylcytosine 5-METHYLCYTIDINE FLUORESCEIN-12-DDCTP BIOTIN-11-DDCTP TEXAS RED-5-DCTP 5-METHYLCYTOSINE 5-CARBOXYCYTOSINE COUMARIN-5-DCTP COUMARIN-5-CTP 5-(TRIFLUOROMETHYL)-2'-DEOXYCYTIDINE 5'-O-(4,4'-DIMETHOXYTRITYL)-5-METHYL-N4-BENZOYL-2'-DEOXYCYTIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE 5-ACETYL-6-METHYL-4-MORPHOLIN-4-YL-1-PHENYLPYRIMIDIN-2(1H)-ONE TETRAMETHYLRHODAMINE-6-DCTP 4-AMINO-6-FLUORO-5-METHYLPYRIMIDIN-2(1H)-ONE

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