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| | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Basic information | | Uses Preparation |
| Product Name: | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol | | Synonyms: | (R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL;(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,99%e.e.;(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%;(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;R-MBT-PEL;(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL | | CAS: | 127852-28-2 | | MF: | C10H8F6O | | MW: | 258.16 | | EINECS: | 603-245-7 | | Product Categories: | API intermediates;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;127852-28-2 | | Mol File: | 127852-28-2.mol | ![(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Structure](CAS/GIF/127852-28-2.gif) |
| | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties |
| Melting point | 53-58℃ | | Boiling point | 175.8±35.0 °C(Predicted) | | density | 1.376±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Acetonitrile (Slightly), Chloroform (Slightly) | | pka | 13.99±0.20(Predicted) | | form | Powder | | color | White | | optical activity | [α]/D +27±1°, c = 1 in acetonitrile | | λmax | 272nm(MeOH)(lit.) | | InChIKey | MMSCIQKQJVBPIR-RXMQYKEDSA-N | | CAS DataBase Reference | 127852-28-2(CAS DataBase Reference) |
| | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Usage And Synthesis |
| Uses | (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions. | | Preparation | At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity. | | Chemical Properties | White fine crystalline powder | | Uses | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. | | General Description | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor. |
| | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials |
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