| | carboquone Basic information |
| Product Name: | carboquone | | Synonyms: | carboquone;Carbazilquinone;Esquinon;Carbazylquinone;2,5-Cyclohexadiene-1,4-dione, 2-[2-[(aminocarbonyl)oxy]-1-methoxyethyl]-3,6-bis(1-aziridinyl)-5-methyl-;Esquinone;NSC 134679;p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6-methyl-, carbamate (ester) (8CI) | | CAS: | 24279-91-2 | | MF: | C15H19N3O5 | | MW: | 321.33 | | EINECS: | | | Product Categories: | | | Mol File: | 24279-91-2.mol |  |
| | carboquone Chemical Properties |
| Melting point | 202° (dec) | | Boiling point | 460.09°C (rough estimate) | | density | 1.1990 (rough estimate) | | refractive index | 1.5600 (estimate) | | pka | 13.14±0.50(Predicted) | | color | Red to reddish-brown crystals |
| Toxicity | LD50 in male mice, male rats (mg/kg): 6.09, 3.88 i.v.; 3.84, 3.16 i.p.; 30.8, 28.0 orally (Masuda, Suzuki) |
| | carboquone Usage And Synthesis |
| Originator | Esquinon,Sankyo,Japan,1974 | | Definition | ChEBI: Carboquone is an organic molecular entity. | | Manufacturing Process | In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1-
methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution
was cooled. To the cooled solution was added 0.5 ml of aziridine and then the
resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4
days. Thereafter, the crystalline substance which precipitated in situ was
recovered by filtration and washed with ethanol to give 50 mg of the desired
product as red crystals melting at 200°C (with decomposition). | | Therapeutic Function | Antineoplastic | | Safety Profile | A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx. |
| | carboquone Preparation Products And Raw materials |
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