Trandolaprilat

Trandolaprilat Basic information
Product Name:Trandolaprilat
Synonyms:1-(2-((1-Carboxy-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylicacid;(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid;Trandolaprilate;(2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid;Trandolaprilat;Trandolapril EP IMpurity E;Trandolapril Related CoMpound E;Trandolaprilat Monohydrate
CAS:87679-71-8
MF:C22H30N2O5
MW:402.48
EINECS:
Product Categories:Trandolapril;Isotope Labeled Compounds;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:87679-71-8.mol
Trandolaprilat Structure
Trandolaprilat Chemical Properties
Melting point 132-134°C
Boiling point 640.5±55.0 °C(Predicted)
density 1.247±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form Solid
pka2.20±0.10(Predicted)
color White to Off-White
Safety Information
HS Code 29339900
MSDS Information
Trandolaprilat Usage And Synthesis
Chemical PropertiesPale Yellow Solid
UsesA labeled metabolite of Trandolapril, an antihypertensive.
UsesA metabolite of Trandolapril, an antihypertensive.
UsesTrandolaprilat (Trandolapril EP Impurity E) is a metabolite of Trandolapril (T713500), an antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.
DefinitionChEBI: Trandolaprilat is a heterobicyclic compound that is trandolapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of the prodrug trandolapril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a drug metabolite and a human xenobiotic metabolite. It is an organic heterobicyclic compound, a dipeptide, a secondary amino compound, a tertiary carboxamide and a dicarboxylic acid.
Trandolaprilat Preparation Products And Raw materials
Hydrochlorothiazide TRANDOLAPRILAT-PHENYL-D5 Carboxy styrene-butadiene latex Indometacin trandolaprilat Indole-3-butyric acid Trandolaprilat Trandolapril Indole-3-acetic acid

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