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FOSINOPRILAT

FOSINOPRILAT Basic information
Product Name:FOSINOPRILAT
Synonyms:FOSINOPRILAT;fosinoprilicacid;Forsinoprilat;4β-Cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline;Fosfenopril;Fospenopril;SQ-27519;Fosinopril Related Compound A (25 mg) ((4S)-4-cyclohexyl-[(4-phenylbutyl)phosphinyl]acetyl-L-proline)
CAS:95399-71-6
MF:C23H34NO5P
MW:435.49
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Chiral Reagents;Phosphorylating and Phosphitylating Agents;Various Metabolites and Impurities;Isotopically Labeled Pharmaceutical Reference Standard
Mol File:95399-71-6.mol
FOSINOPRILAT Structure
FOSINOPRILAT Chemical Properties
Melting point >3000C
alpha D -24° (c = 1 in methanol)
Boiling point 728.9±60.0 °C(Predicted)
density 1.238±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Methanol (Slightly), Water (Slightly)
pka2.75±0.50(Predicted)
form Solid
color White to Off-White
Stability:Hygroscopic
Safety Information
WGK Germany 3
HS Code 2933995300
MSDS Information
FOSINOPRILAT Usage And Synthesis
Chemical PropertiesWhite Crystalline Solid
UsesA metabolite of Fosinopril, a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor
UsesFosinoprilat (Fosinopril EP Impurity A) is a metabolite of Fosinopril (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor.
DefinitionChEBI: A phosphinic acid-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. An inhibitor of angiotensin converting enzyme (ACE), it is used as the phosphinate ester pro-drug fosinopril for treatment of ypertension and chronic heart failure.
FOSINOPRILAT Preparation Products And Raw materials
Fluvastatin sodium salt Des(4-cyclohexyl-L-proline) Fosinopril Acetic Acid Fluvastatin EP impurity A -G sodium:(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-[4-(2,3,4,5,6-pentadeuteriophenyl)butyl]phosphoryl]acetyl]pyrrolidine-2-carboxylate trans-4-Cyclohexyl-L-proline hydrochloride Fulvestrant 1-(1-Oxopropyl)-(4S)-4-cyclohexyl-L-proline Losartan potassium PILSICAINIDE Fosinopril sodium FLUTICASONE PROPIONATE, 17-BETA CARBOXYLIC ACID FOSINOPRILAT SODIUM SALT FOSINOPRILAT-D7 Fosinopril FOSINOPRILAT FOSINOPRILAT, SODIUM SALT FOSINOPRIL-PHENYL-D5 SODIUM SALT Fosinoprilat-phenyl-D5 Sodium Salt
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