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| | 5-METHOXYFLAVONE Basic information |
| Product Name: | 5-METHOXYFLAVONE | | Synonyms: | METHOXYFLAVONE, 5-;5-METHOXYFLAVONE;5-methoxy-2-phenyl-4-benzopyrone;5-Methoxyflavone,97%;5-Methoxy-2-phenyl-4H-1-benzopyran-4-one;5-methoxy-2-phenyl-chromen-4-one;5-methoxy-2-phenylchromen-4-one;5-methoxy-2-phenyl-chromone | | CAS: | 42079-78-7 | | MF: | C16H12O3 | | MW: | 252.26 | | EINECS: | 255-652-0 | | Product Categories: | Mono-substituted Flavones | | Mol File: | 42079-78-7.mol |  |
| | 5-METHOXYFLAVONE Chemical Properties |
| Melting point | 131-133°C | | Boiling point | 422.5±45.0 °C(Predicted) | | density | 1,155g/cm | | refractive index | 1,548 | | storage temp. | Store at -20°C | | solubility | soluble in Methanol | | form | powder to crystal | | color | White to Almost white | | LogP | 3.470 (est) | | CAS DataBase Reference | 42079-78-7(CAS DataBase Reference) |
| | 5-METHOXYFLAVONE Usage And Synthesis |
| Uses | 5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation. | | Definition | ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids. | | Biological Activity | 5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors. | | in vitro | 5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner. | | in vivo | 5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals. | | target | | Target | Value | DNA polymerase β
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| | 5-METHOXYFLAVONE Preparation Products And Raw materials |
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