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Aprepitant

Aprepitant Basic information
Product Name:Aprepitant
Synonyms:Fosaprepitant Impurity 27;Aprepitant impurity 20/Fosaprepitant Morpholine;Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3S)-;Fosaprepitant Morpholine;Aprepitant M2 Metabolite (1R, 2S, 3S)-Isomer
CAS:170902-80-4
MF:C20H18F7NO2
MW:437.35
EINECS:
Product Categories:
Mol File:170902-80-4.mol
Aprepitant Structure
Aprepitant Chemical Properties
Boiling point 387.9±42.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka6.93±0.60(Predicted)
Safety Information
MSDS Information
Aprepitant Usage And Synthesis
UsesFosaprepitant Morpholine is an impurity of Fosaprepitant (F727300). Fosaprepitant (F727300) is a selective neurokinin-1 (NK-1) receptor antagonist and is an antiemetic drug, a Aprepitant (A729800) prodrug.
Aprepitant Preparation Products And Raw materials
(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine Benzyl dihydrogen phosphate (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride Aprepitant Aprepitant Impurity 17 1,1,1-Trimethoxy-2-chloroethane (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one Fosaprepitant Impurity 5 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Fosaprepitant Impurity 6 Aprepitant Aprepitant
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