(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE

(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE Basic information

Product Name:	(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE
Synonyms:	(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE;(11AS)-(-)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1-PHENYLETHYL]AMINE;N-DI[(R)-1-PHENYLETHYL]-[(R)-1,1'-SPIROBIINDANE-7,7'-DIYL]-PHOSPHORAMIDITE;N-DI[(R)-1-PHENYLETHYL]-[(S)-1,1'-SPIROBIINDANE-7,7'-DIYL]-PHOSPHORAMIDITE;(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine,min.98%(R)-SIPHOS-PE;N-Di[(R)-1-phenylethyl]-[(R)-1,1'-spirobiindane-7,7'-diyl]-phosphoramidite ,98%;(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine;(11aR)-10,11,12,13-tetrahydro-N,N-bis[(1R)-1-phenylethyl]-Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-aMine
CAS:	500997-69-3
MF:	C33H32NO2P
MW:	505.59
EINECS:
Product Categories:	Chiral Phosphine;Chiral Spiro Ligand;CPN
Mol File:	500997-69-3.mol

(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE Chemical Properties

Melting point	98-100°C
alpha	+300° (c 1.0, CH2Cl2)
Boiling point	617.8±65.0 °C(Predicted)
storage temp.	-20°C
pka	0.40±0.20(Predicted)
form	solid
color	white
optical activity	[α]22/D +337°, c = 1 in chloroform
Sensitive	moisture sensitive
InChIKey	ZXLQLIDJAURBDD-HRPAVAKOSA-N

Safety Information

MSDS Information

(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE Usage And Synthesis

Chiral ligands for copper-catalyzed asymmetric allylic alkylation with dialkylzincs.
Chiral ligands for copper-catalyzed asymmetric conjugate addition of diethylzinc to enones.
Chiral ligands for palladium-catalyzed asymmetric hydrosilylation of styrenes
Chiral ligands for copper-catalyzed asymmetric ring-opening of oxabicyclic alkenes with Grignard reagents.
Chiral ligands for nickel-catalyzed asymmetric hydrovinylation of α-alkyl vinylarenes.
Chiral ligands for iridium-catalyzed asymmetric hydrogenation of cyclic enamines.
Chiral ligands for iridium-catalyzed asymmetric hydrogenation of cyclic imines.
Chiral ligands for gold-catalyzed asymmetric [2 + 2] cycloaddition reaction.
Chiral ligands for rhodium-catalyzed asymmetric hydroacylation of salicylaldehydes to homoallylic sulfides.
Chiral ligands for palladium-catalyzed asymmetric carboamination reactions.

Uses

(R)-SIPHOS-PE can be used as:

A catalyst in the preparation of tricyclic alkaloid (+)-aphanorphine via asymmetric carboamination and Friedel?Crafts reaction.
A ligand in the synthesis of chiral ketones via hydroacylation of olefins using salicylaldehyde derivatives.
A ligand in the enantioselective synthesis of substituted pyrrolidine derivatives via Pd-catalyzed alkene aminoarylation reactions.

(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE Preparation Products And Raw materials

Raw materials

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