LOXO-292

LOXO-292 Basic information
Product Name:LOXO-292
Synonyms:RET-IN-1;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[5-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-2-pyrazinyl]-6-[(2R)-2-morpholinylmethoxy]-;RET IN 1,RETIN1
CAS:2222755-14-6
MF:C29H31N9O3
MW:553.61
EINECS:
Product Categories:
Mol File:2222755-14-6.mol
LOXO-292 Structure
LOXO-292 Chemical Properties
density 1.49±0.1 g/cm3(Predicted)
storage temp. Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
solubility Soluble in DMSO
pka8.23±0.40(Predicted)
form solid
Safety Information
MSDS Information
LOXO-292 Usage And Synthesis
DescriptionRET-IN-1 is an oral and selective investigational drug in clinical development for the treatment of patients with cancers that harbor abnormalities in the rearranged during transfection (RET) kinase.
LOXO-292 Preparation Products And Raw materials
Olaparib Lorlatinib (PF-06463922) 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Crizotinib LOXO-292 Brigatinib 2-Amino-6-bromopyridine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

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