ChemicalBook Product Catalog Organic Chemistry Heterocyclic Compounds 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE

4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE

4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Basic information
Product Name:4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
Synonyms:4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE;IMMEPIP DIHYDROBROMIDE;Zinc00005777;4-(1H-Imidazol-5-ylmethyl)piperidine hydrobromide;Immepip hydrobromide;Piperidine,4-(1H-imidazol-4-ylmethyl)-,dihydrobromide
CAS:164391-47-3
MF:C9H17Br2N3
MW:327.06
EINECS:
Product Categories:Inhibitors;Histamine receptor
Mol File:164391-47-3.mol
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Structure
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Chemical Properties
Melting point 234-235℃
storage temp. 2-8°C
solubility H2O: 7 mg/mL at <40 °C
form solid
color light tan
Water Solubility Soluble to 100 mM in water
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Usage And Synthesis
DescriptionImmepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.
Chemical PropertiesCrystalline Solid
UsesA selective nonchiral histamine H3 agonist.
Biological ActivityPotent histamine H 3 receptor agonist. Also binds to H 4 receptors (K i values are 0.4 and 9 nM at human recombinant H 3 and H 4 receptors respectively). Equipotent to or slightly more active than (R)- α -methylhistamine at H 3 receptors.
storageDesiccate at RT
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Preparation Products And Raw materials
4-(IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
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