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| | 3,5-Lutidine Basic information |
| Product Name: | 3,5-Lutidine | | Synonyms: | pyridine,3,5-dimethyl-;Lutidine,98%;3 5-LUTIDINE STANDARD FOR GC;3,5-LUTIDINE, 98+%;3,5-DIMETHYLPYRIDINE 98+%;3,5-Dimetylpyridine;3,5-Lutidine,99%;3,5-dimethyl-pyridin | | CAS: | 591-22-0 | | MF: | C7H9N | | MW: | 107.15 | | EINECS: | 209-708-6 | | Product Categories: | Biochemistry;Reagents for Oligosaccharide Synthesis;Pyridines derivates;Heterocyclic Compounds;K00001 | | Mol File: | 591-22-0.mol |  |
| | 3,5-Lutidine Chemical Properties |
| Melting point | -9 °C (lit.) | | Boiling point | 169-170 °C (lit.) | | density | 0.939 g/mL at 25 °C (lit.) | | vapor pressure | 1.5 mm Hg ( 20 °C) | | refractive index | n20/D 1.504(lit.) | | Fp | 128 °F | | storage temp. | 2-8°C | | solubility | Sol | | pka | 6.15(at 25℃) | | form | Liquid | | color | Clear yellow | | Water Solubility | 33 g/L (20 ºC) | | Sensitive | Hygroscopic | | BRN | 105682 | | InChIKey | HWWYDZCSSYKIAD-UHFFFAOYSA-N | | LogP | 1.780 | | CAS DataBase Reference | 591-22-0(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, 3,5-dimethyl-(591-22-0) | | EPA Substance Registry System | 3,5-Dimethylpyridine (591-22-0) |
| | 3,5-Lutidine Usage And Synthesis |
| Chemical Properties | CLEAR YELLOW LIQUID | | Uses | 3,5-Lutidine is a reactant used in the synthesis of phthalazine and pyrazine compounds, as well as other pharmaceuticals. | | Synthesis Reference(s) | Synthesis, p. 573, 1994 DOI: 10.1055/s-1994-25526 | | Flammability and Explosibility | Flammable | | Purification Methods | Dry 3,5-lutidine with sodium and fractionally distil it through a Todd column (p 11) packed with glass helices. Dissolve (100mL) in dilute HCl (1:4) and steam distil this until 1L of distillate is collected. Excess conc NaOH is added to the residue which is again steam distilled. The base is extracted from the distillate, using diethyl ether. The extract is dried over K2CO3, and distilled. It is then fractionally crystallised by partial freezing. The hydrochloride has m 229o(sublimes at 190-231o), and the picrate has m 242-243o(dec, from H2O), 249-250o(dec, from AcOH). [Beilstein 20 II 161, 20 III/IV 2788, 20/6 V 60.] |
| | 3,5-Lutidine Preparation Products And Raw materials |
| Raw materials | Methyl vinyl sulfone | | Preparation Products | 5-Methylpyridin-3-amine-->3,5-DIMETHYLPYRIDIN-4-AMINE-->3,5-bis(chloromethyl)pyridine-->ETHYL METHYLPHOSPHONIC ACID-->3-CYANO-5-METHYLPYRIDINE-->METHYL 5-METHYLNICOTINATE-->2,3,5-Collidine-->1,3,5-Trimethyl-1,2-dihydropyridin-2-one-->1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-diMethylethyl)-5-Methyl--->3,5-Dimethylpiperidine-->3,5-dimethylpyridine-4-carboxylic acid |
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