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| | N-desalkylflurazepam Basic information |
| | N-desalkylflurazepam Chemical Properties |
| Melting point | 204-206°C | | Boiling point | 454.0±45.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | A neat solid | | pka | 11.55±0.70(Predicted) | | InChI | InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20) | | InChIKey | UVCOILFBWYKHHB-UHFFFAOYSA-N | | SMILES | N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O | | CAS DataBase Reference | 2886-65-9(CAS DataBase Reference) | | NIST Chemistry Reference | Norfludiazepam(2886-65-9) |
| | N-desalkylflurazepam Usage And Synthesis |
| Description | Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications. | | Chemical Properties | Light Yellow Solid | | Uses | The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase | | Definition | ChEBI: Desalkylflurazepam is a benzodiazepine. | | General Description | N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward. | | Mode of action | N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward. |
| | N-desalkylflurazepam Preparation Products And Raw materials |
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