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| | O-Methyl Dolutegravir Basic information |
| Product Name: | O-Methyl Dolutegravir | | Synonyms: | (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide;Dolutegravir O-Methyl Imp;Dolutegravir impurity 5/O-Methyl Dolutegravir/(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-, (4R,12aS)-;O-Methyl Dolutegravir;BNKY001-DL03;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-car boxamide | | CAS: | 1335210-35-9 | | MF: | C21H21F2N3O5 | | MW: | 433.41 | | EINECS: | | | Product Categories: | CMLLYL | | Mol File: | 1335210-35-9.mol |  |
| | O-Methyl Dolutegravir Chemical Properties |
| Boiling point | 684.3±55.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 10.70±0.40(Predicted) |
| | O-Methyl Dolutegravir Usage And Synthesis |
| Description | Dolutegravir intermediate is a new synthetic intermediate of Dolutegravir. Dolutegravir is an integrase inhibitor used to treat human immunodeficiency virus (HIV)-1 infection. | | Uses | (4R,12AS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide is an intermediate in the preparation of dolutegravir, an integrase inhibitor for HIV-1 infection therapy. |
| | O-Methyl Dolutegravir Preparation Products And Raw materials |
| Raw materials | (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid-->2,4-Difluorobenzylamine | | Preparation Products | Dolutegravir sodium |
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