MK-2048

MK-2048 Basic information
Product Name:MK-2048
Synonyms:Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-;CS-1529;(S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-diMethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxaMide;(6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxopyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide;MK-2048 USP/EP/BP;MK-2048 MK2048
CAS:869901-69-9
MF:C21H21ClFN5O4
MW:461.87
EINECS:
Product Categories:Inhibitors
Mol File:869901-69-9.mol
MK-2048 Structure
MK-2048 Chemical Properties
density 1.55
storage temp. Store at -20°C
solubility Soluble in DMSO > 10 mM
form Powder
pka6.30±0.40(Predicted)
Safety Information
MSDS Information
MK-2048 Usage And Synthesis
UsesMK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
UsesMK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
targetsubtype B integrase
MK-2048 Preparation Products And Raw materials
Elvitegravir PLX4032 Entinostat Raltegravir GSK1349572 BMS707035

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