(S) - N- Boc- adamantylglycine
(S) - N- Boc- adamantylglycine Basic information
Product Name: (S) - N- Boc- adamantylglycine Synonyms: (alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]tricyclo[3.3.1.13,7]decane-1-acetic acid ;N-Boc-L-Adamantylglycine ;(S)-Boc-adamantylglycine ;N-Boc-AdGly ;Saxagliptin impurity E ;(S)-Adamantylglycine ;(2S)-2-(AdaMantan-1-yl)-2-((tert-butoxycarbonyl)aMino)acetic acid ;(S) - N- Boc- adamantylglycine CAS: 361441-97-6 MF: C17H27NO4 MW: 309.4 EINECS: Product Categories: Mol File: 361441-97-6.mol
(S) - N- Boc- adamantylglycine Chemical Properties
Melting point >300 °C (decomp)(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4)) Boiling point 460.3±28.0 °C(Predicted) density 1.193 storage temp. 2-8°C solubility Chloroform (Slightly), DMSO (Slightly) pka 4.21±0.10(Predicted) form Solid color White to Off-White
(S) - N- Boc- adamantylglycine Usage And Synthesis
Uses (S)-Boc-adamantylglycine is used to prepare saxagliptin (BMS-477118) as highly potent and long-acting and orally active dipeptidyl peptidase IV inhibitor for treatment of type 2 diabetes.
(S) - N- Boc- adamantylglycine Preparation Products And Raw materials
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S)-
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3R,5S)- (1S,3S,5S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID
1H-Pyrrole-1-carboxylic acid, 2-(aMinocarbonyl)-2,3-dihydro-, 1,1-diMethylethyl ester, (2S)- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-
(1R,3S,5R)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXAMIDE 2,2,2-TRIFLUOROACETIC ACID 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3S,5R)-
Hydroxy Saxagliptin (R)-N-Boc-3-hydroxyadaMantylglycine
Saxagliptin Impurity 34 3-Hydroxy-1-AdaMantane Carboxylic Acid
(1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate 1H-Cyclopropa[4,5]pyrrolo[1,2-a]pyrazine-3,6-dione, hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-, (1aS,4S,6aR,7aS)-
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3S,5R)- Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-diMethylethoxy)carbonyl]aMino]-3,5-dihydroxy-, (αS)-
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3R,5S)-
Saxagliptin iMpurity
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