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| | Fluocinonide Basic information |
| | Fluocinonide Chemical Properties |
| Melting point | 309 °C | | alpha | D +83° (chloroform) | | Boiling point | 235°C (rough estimate) | | density | 1.2001 (estimate) | | storage temp. | 2-8°C | | solubility | DMSO: ≥19mg/mL | | pka | 12.77±0.70(Predicted) | | form | powder | | color | white to tan | | optical activity | [α]/D +75 to +90°, c = 1 in dichloromethane | | Water Solubility | 0.53mg/L(25 ºC) | | InChIKey | WJOHZNCJWYWUJD-IUGZLZTKSA-N |
| Hazard Codes | T+ | | Risk Statements | 28-63 | | Safety Statements | 22-25-28-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | RTECS | TU3831000 | | HazardClass | 6.1(a) | | PackingGroup | I | | HS Code | 2937220000 | | Toxicity | guinea pig,LD50,subcutaneous,> 3170mg/kg (3170mg/kg),Drugs in Japan Vol. 6, Pg. 694, 1982. |
| | Fluocinonide Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Topsyn ,Recordati,Italy,1970 | | Uses | Glucocorticoid; anti-inflammatory. | | Uses | Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid. | | Indications | Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid. | | Definition | ChEBI: Fluocinonide is an organic molecular entity. | | Manufacturing Process | To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is
added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room
temperature for 3 hours. During this period the crystals gradually dissolve and
the clear solution is neutralized with dilute bicarbonate and the acetone
removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95%
alcohol to give the pure acetonide.
A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine
and 1 ml of acetic anhydride is allowed to stand at room temperature for 18
hours. Removal of the reagents in vacuo gives a crystalline residue which
after crystallization from acetone-hexane gives the pure 16α,17α-
isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described
in US Patent 3,197,469. | | Brand name | Lidex (Medicis); Vanos (Medicis). | | Therapeutic Function | Antiinflammatory, Glucocorticoid | | Biochem/physiol Actions | Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells. |
| | Fluocinonide Preparation Products And Raw materials |
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