Nimustine

Nimustine Basic information
Product Name:Nimustine
Synonyms:1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE;1-((4-amino-2-methylpyrimidin-5-yl)methyl)-3-(2-chloroethyl)-3-nitrosourea;NIMUSTINE;NIMUSTINE HCL;N'-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-N-(2-CHLORETHYL)-N-NITROSOUREA;ACNU;3-(4-amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea;n’-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(2-chloroethyl)-n-nitroso-ure
CAS:42471-28-3
MF:C9H13ClN6O2
MW:272.69
EINECS:255-838-1
Product Categories:
Mol File:42471-28-3.mol
Nimustine Structure
Nimustine Chemical Properties
Melting point 125°C (rough estimate)
Boiling point 98°C (rough estimate)
density 1.9048 (rough estimate)
refractive index 1.5790 (estimate)
pka9.58±0.46(Predicted)
form solid
CAS DataBase Reference42471-28-3(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS YR8450000
MSDS Information
ProviderLanguage
SigmaAldrich English
Nimustine Usage And Synthesis
OriginatorNidran,Sankyo,Japan,1979
DefinitionChEBI: An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An anti eoplastic agent especially effective against malignant brain tumors.
Manufacturing Process0.4 g of sodium nitrite was added with stirring, at 0°C to 5°C, to a solution of 450 mg of 1-(2-chloroethyl)-3-[(2-methyl-4-aminopyridin-5-yl)methyl]urea in 8 ml of 5% hydrochloric acid, and the reaction mixture was then stirred at 0°C to 10°C for an additional 1.5 hours.
After completion of the reaction, the reaction mixture was made alkaline by the addition of sodium carbonate, whereupon crystals separated out in situ. The crystals were recovered by filtration, washed with water and then recrystallized from 6 ml of ethanol, to give 0.1 g of the pale yellow pure desired product having a decomposition point of 125°C.
Therapeutic FunctionAntitumor, Antileukemic
Nimustine Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Sodium nitrite
N-NITROSOMETHYL-2-CHLOROETHYLAMINE Bendamustine hydrochloride Methyl Bendamustine NIMUSTINE HYDROCHLORIDE,NIMUSTINE HCL N,N'-dimethylnitrosourea 1-Methyl-1-nitrosourea 1-(2-chloroethyl)-1-nitrosourea 1-nitroso-1-ethyl-3-methylurea NIMUSTINE HCL Kresoxim-methyl 3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)urea Thiophanate-methyl N-NITROSO-N-ETHYLUREA Predmustine METSULFURON METHYL N-Nitrocarbamide 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.