ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluoroaniline series 3-Chloro-4-fluoroaniline

3-Chloro-4-fluoroaniline

3-Chloro-4-fluoroaniline Basic information
Product Name:3-Chloro-4-fluoroaniline
Synonyms:3－chloro-4-fluoroanilinc;3-CHLORO-4-FLUOROANILINENORFLOXACIN;3-CHLORO-4-FLUOROANILINE pure;3-/4-CHLOROFLUOROANILINE;Benzenamine, 3-chloro-4-fluoro-;3-Chloro-4-fluoroaniline 98%;Chloro-4-fluoroanil;Gefitinib IMpurity V
CAS:367-21-5
MF:C6H5ClFN
MW:145.56
EINECS:206-682-8
Product Categories:Furans ,Coumarins;Anilines, Aromatic Amines and Nitro Compounds;Aniline series;Fluorobenzene;API Intermediate;C2 to C6;Nitrogen Compounds;ChloroChemical Class;FluoroMore...Close...;Alpha Sort;Amines;Analytical Standards;AromaticsChemical Class;AromaticsVolatiles/ Semivolatiles;C;CAlphabetic;CHChemical Class;Chemical Class;Halogenated;Drug Intermediates
Mol File:367-21-5.mol
3-Chloro-4-fluoroaniline Structure
3-Chloro-4-fluoroaniline Chemical Properties
Melting point 42-44 °C (lit.)
Boiling point 227-228 °C (lit.)
density 1,226 g/cm3
vapor pressure 0.01 hPa (20 °C)
refractive index 1,54-1,542
Fp >230 °F
storage temp. Store below +30°C.
solubility 10g/l
pka3.60±0.10(Predicted)
form Crystalline Solid
color Beige to brown
PH7 (10g/l, H2O, 20℃)
Water Solubility 10 g/L (20 ºC)
BRN 1562786
Stability:Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
InChIKeyYSEMCVGMNUUNRK-UHFFFAOYSA-N
CAS DataBase Reference367-21-5(CAS DataBase Reference)
EPA Substance Registry System3-Chloro-4-fluoroaniline (367-21-5)
Safety Information
Hazard Codes T,Xi,Xn
Risk Statements 23/24/25-33-36/37/38-20/21/22
Safety Statements 36/37/39-45-26
RIDADR UN 2811 6.1/PG 2
WGK Germany 2
F 9-23
Hazard Note Irritant/Toxic
TSCA T
HazardClass TOXIC
HazardClass 6.1
PackingGroup III
HS Code 29214210
ToxicityLD50 orally in Rabbit: 506 mg/kg
MSDS Information
ProviderLanguage
3-Chloro-4-fluoroaniline English
SigmaAldrich English
ACROS English
ALFA English
3-Chloro-4-fluoroaniline Usage And Synthesis
Chemical Propertiesdark purple to black solid
Uses4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.
General DescriptionThe exposure of workers to 3-chloro-4-fluoroaniline (CFA) was monitored by an HPLC method.
N-[1-(4-tert-butylphenyl)ethyl]-2-chloro-4-fluoroaniline 4-CHLORO-2-(3-CHLORO-4-FLUOROPHENYL)-5-(1-METHYL-HYDRAZINO)-3-(2H)-PYRIDAZINONE 4-Chloro-2-Fluoroaniline/2-Fluoro-4-Chloroaniline/ N-[1-(3-bromophenyl)ethyl]-2-chloro-4-fluoroaniline 4-Bromo-2-chloro-6-fluoroaniline 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-4-CYANOPYRAZOLE 2-(3-CHLORO-4-FLUOROPHENYL)-4,5-DICHLORO-PYRIDAZINE-3-(2H)-ONE FLAMPROPO-METHYL N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE N-[1-(adamantan-1-yl)ethyl]-3-chloro-4-fluoroaniline 2-Fluoro-5-Chloroaniline /5-Chloro-2-Fluoroaniline / 2-Chloro-3-fluoroaniline98%,2-Chloro-3-fluoroaniline 98% 3-CHLORO-2,4-DIFLUOROANILINE 99 2,4-Difluoro-3,5-dichloroaniline N-[1-(3-bromophenyl)ethyl]-3-chloro-4-fluoroaniline N-[1-(adamantan-1-yl)ethyl]-2-chloro-4-fluoroaniline N-[1-(adamantan-1-yl)ethyl]-3-chloro-2-fluoroaniline
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