ChemicalBook Product Catalog API Circulatory system drugs Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Basic information
Product Name:Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate
Synonyms:4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;1H-Imidazole-4-carboxylicacid,5-(1-hydroxy-1-met;1H-Imidazole-5-carboxylicacid,4-(1-hydroxy-1-met;ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE;1H-Imidazole-4-carboxylic acid,5-(1-hydroxy-1-methylethyl)-2- propyl-,ethyl ester;Olmesartan intermediate;5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER;4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 98+%
CAS:144689-93-0
MF:C12H20N2O3
MW:240.3
EINECS:1592732-453-0
Product Categories:API intermediates;Heterocycles;INTERMEDIATESOF;Imidazol&Benzimidazole;Intermediates & Fine Chemicals;Pharmaceuticals;144689-93-0
Mol File:144689-93-0.mol
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Structure
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Chemical Properties
Melting point 98-100°C
Boiling point 456.2±35.0 °C(Predicted)
density 1.131±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Chloroform, Ethyl Acetate, Methanol
form Solid
pka11.61±0.10(Predicted)
color Pale Yellow
InChIInChI=1S/C12H20N2O3/c1-5-7-8-13-9(11(15)17-6-2)10(14-8)12(3,4)16/h16H,5-7H2,1-4H3,(H,13,14)
InChIKeyKZBJJAFGNMRRHN-UHFFFAOYSA-N
SMILESC1(CCC)NC(C(OCC)=O)=C(C(O)(C)C)N=1
CAS DataBase Reference144689-93-0(CAS DataBase Reference)
Safety Information
HS Code 2933.29.9000
MSDS Information
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Usage And Synthesis
Chemical PropertiesPale Yellow Solid
UsesAn Olmesartan (O550000) intermediate.
UsesOlmesartan (O550000) intermediate.
ApplicationEthyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a synthetic drug with pharmacological properties that are similar to those of the natural product medoxomil. It has been shown to be a potent blocker of the GABA receptor and is used for the treatment of epilepsy.It has been shown to be an inhibitor of rat liver microsomes and also has a high affinity for the enzyme cilexetil, which is responsible for the conversion of cilexetil into its active form.
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Preparation Products And Raw materials
Preparation ProductsOlmesartan Medoxomil-->Trityl olmesartan-->Trityl Olmesartan Medoxomil-->1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester
N-Trityl Olmesartan Ethyl Ester OlMesartan MedoxoMil iMpurity V Calcitonin salmon Olmesartan 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one 2,2'-(2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-diyl)bis(propan-2-ol) 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 5-[4’-Hydroxymethyl-(1,1’-biphenyl)-2-yl]-1-triphenylmethyltetrazole Olmesartan OlMesartan Methyl Ester Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Imidazole N-TRITYL OLMESARTAN-D6 ETHYL ESTER 2-Propylimidazole 4-ISOPROPYL-2-METHYLIMIDAZOLE 5-(HYDROXYMETHYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER Trityl olmesartan 2-ETHYL-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID
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