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| | psoralidin Basic information |
| Product Name: | psoralidin | | Synonyms: | 3,9-Dihydroxy-2-prenylcoumestan;Psoralidin, >=99%;psoralidin;3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one;Psorslidin;Psoralidin, BR;6H-Benzofuro[3,2-c][1]benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-buten-1-yl)-;3,9-Dihydroxy-2-(3-methylbut-2-en-1-yl)-6H-benzofuro[3,2-c]chromen-6-one | | CAS: | 18642-23-4 | | MF: | C20H16O5 | | MW: | 336.34 | | EINECS: | | | Product Categories: | | | Mol File: | 18642-23-4.mol |  |
| | psoralidin Chemical Properties |
| Melting point | 290-292° | | Boiling point | 458.8±34.0 °C(Predicted) | | density | 1.383±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | pka | 8.70±0.20(Predicted) | | form | powder | | color | white to beige | | InChIKey | YABIJLLNNFURIJ-UHFFFAOYSA-N |
| WGK Germany | 3 | | HS Code | 2932.20.4500 |
| | psoralidin Usage And Synthesis |
| Description | Psoralidin is a furanocoumarin isolated from the seeds of P. corylifolia, a medicinal plant found in southeastern Asia, that has been shown to induce cytotoxicity against various cancer cells. Through TNF-related apoptosis-inducing ligand-mediated events, psoralidin at 50 μM can induce the death of HeLa cancer cells. It also can induce apoptosis of androgen-dependent (LNCaP, C4-2B) and androgen-independent (DU-145, PC-3) prostate cancer cells and inhibit the growth of PC-3 xenograft tumors in nude mice. | | Uses | Psoralidin is an antibacterial and antioxidant reagent. | | Definition | ChEBI: A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively. | | references | [1] yang h j, youn h s, seong k m, et al. psoralidin, a dual inhibitor of cox-2 and 5-lox, regulates ionizing radiation (ir)-induced pulmonary inflammation[j]. biochemical pharmacology, 2011, 82(5): 524-534.
[2] chiou w f, don m j, liao j f, et al. psoralidin inhibits lps-induced inos expression via repressing syk-mediated activation of pi3k-ikk-iκb signaling pathways[j]. european journal of pharmacology, 2011, 650(1): 102-109.
[3] bronikowska j, szliszka e, jaworska d, et al. the coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (trail)[j]. molecules, 2012, 17(6): 6449-6464. |
| | psoralidin Preparation Products And Raw materials |
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