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| | 2-Iodophenylacetic acid Basic information |
| | 2-Iodophenylacetic acid Chemical Properties |
| Melting point | 116-119 °C (lit.) | | Boiling point | 344.5±17.0 °C(Predicted) | | density | 1.885±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | pK1:4.038 (25°C) | | form | Powder | | color | Cream | | Sensitive | Light Sensitive | | BRN | 2086800 | | CAS DataBase Reference | 18698-96-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37 | | WGK Germany | 3 | | Hazard Note | Irritant/Light Sensitive | | HazardClass | IRRITANT, LIGHT SENSITIVE | | HS Code | 29163990 |
| | 2-Iodophenylacetic acid Usage And Synthesis |
| Chemical Properties | Cream powder | | Uses | 2-Iodophenylacetic acid is a synthetic intermediate that is widely used in the chemical, pharmaceutical and cosmetic industries. 2-Iodophenylacetic acid is also used as a reagent to synthesize Cepharanone B, a natural and potentially antineoplastic aristolactam that is found in Piper longum (a medicinal plant native to India). | | Application | 2-Iodophenylacetic acid may be used in the preparation of:
2-iodophenylacetyl chloride
3,4-dimethoxyphenyl 2-iodophenylacetate
N-{2-[2-(2-iodophenyl)-acetylamino]-ethyl}-2-(3,4- dichlorophenyl)-acetamide | | Preparation | synthesis of 2-Iodophenylacetic acid: The anthranilic acid solution was acidified with sulfuric acid to pH = 1 followed by a diazotization reaction. The diazonium was added dropwise to the potassium iodide-sulfuric acid solution (3.5 g KI, 1.0 mL concentrated H2SO4, 5 mL water) preheated to 60-70 °C, stirred for 30 min, placed overnight, and filtered to obtain the product. Recrystallization with 50% ethanol aqueous solution gave 3.83 g of 2-iodophenylacetic acid, the yield was 73% (calculated as o-nitrophenylacetic acid), and the melting point was 113-115 °C (117 °C reported in the literature). | | General Description | 2-Iodophenylacetic acid is a substituted acetic acid that can be prepared from 2-iodobenzyl cyanide. It undergoes palladium-catalyzed reaction with allenes to form 1,3-butadienes. 2-Iodophenylacetic acid also undergoes photolysis in carbon tetrachloride to form the corresponding chloro compound. |
| | 2-Iodophenylacetic acid Preparation Products And Raw materials |
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