Adipic dihydrazide

Adipic dihydrazide Basic information
Product Name:Adipic dihydrazide
Synonyms:ADH;ADIPINIC DIHYDRAZIDE;ADIPIC DIHYDRAZIDE;ADIPIC ACID DIHYDRAZIDE;ADIPIC ACID DIHYDRIZIDE;adipoyl hydrazide;ADIPODIHYDRAZIDE;Adipohydrazide
CAS:1071-93-8
MF:C6H14N4O2
MW:174.2
EINECS:213-999-5
Product Categories:Pharmaceutical intermediates;chemical;Carbonyl Compounds;Homobifunctional Cross-Linking Reagents;Crosslinking;Protein Modification;Industrial/Fine Chemicals;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Ester series;Hydrazides;Organic Building Blocks;bc0001;1071-93-8
Mol File:1071-93-8.mol
Adipic dihydrazide Structure
Adipic dihydrazide Chemical Properties
Melting point 180-182 °C (lit.)
Boiling point 305.18°C (rough estimate)
density 1.2297 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.6700 (estimate)
Fp 150 °C
storage temp. -20°C
solubility H2O: 100 mg/mL
pka12.93±0.35(Predicted)
form Crystalline Powder
color White to slightly yellow
Water Solubility soluble
BRN 973863
InChIKeyIBVAQQYNSHJXBV-UHFFFAOYSA-N
LogP-2.7 at 20℃
CAS DataBase Reference1071-93-8(CAS DataBase Reference)
NIST Chemistry ReferenceAdipic dihydrazide(1071-93-8)
EPA Substance Registry SystemHexanedioic acid, dihydrazide (1071-93-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25
WGK Germany 3
RTECS AV1400000
Autoignition Temperature360 °C
TSCA Yes
HazardClass IRRITANT
HS Code 29280090
MSDS Information
ProviderLanguage
Hexanedioic acid dihydrazide English
SigmaAldrich English
ACROS English
ALFA English
Adipic dihydrazide Usage And Synthesis
DescriptionAdipic dihydrazide (ADH) is the most suitable hydrazide cross-linking agent, and ADH has been widely used in water-based paint emulsions in combination with diacetone acrylamide. ADH is weakly alkaline, and there is a possibility of agglomeration when solid ADH is added directly to the emulsion, so usually ADH should be dissolved in hot water before use.
Chemical Propertieswhite to slightly yellow crystalline powder
UsesAdipic dihydrazide is used as a formaldehyde scavenger and reacts with formaldehyde, thereby preventing the volatilizing of formaldehyde in the air. It is also employed as a paint additive and coating additive. It is also used as an intermediate. Further, it is used for cross-linking water-based emulsions and as a hardener for certain epoxy resins, which finds application in powder coating.
UsesAdipic acid dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.
Flammability and ExplosibilityNonflammable
Adipic dihydrazide Preparation Products And Raw materials
Decanedihydrazide Tebufenozide Adipic acid Adopyl diacidhydrizine Hyaluronic acid SALOR-INT L105201-1EA Oxalyl dihydrazide SALOR-INT L105198-1EA Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid hexanedioic acid Butanedihydrazide Adipic dihydrazide Folic acid Maleic hydrazide METHOXYFENOZIDE DIPHENYLCARBAZONE Citric acid Adipic Acid Dihydrazide

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