|
| | 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Basic information | | Synthesis |
| Product Name: | 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine | | Synonyms: | 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97%;1-Benzyl-4-(5,6-dimethoxy-1-ox;2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE;1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-;1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine;2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one;2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one;Dehydro Donepezil (Donepezil Impurity) | | CAS: | 120014-07-5 | | MF: | C24H27NO3 | | MW: | 377.48 | | EINECS: | 601-652-4 | | Product Categories: | Aromatics;Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 120014-07-5.mol |  |
| | 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Chemical Properties |
| Melting point | 176-178°C | | Boiling point | 542.8±50.0 °C(Predicted) | | density | 1.209±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 8.03±0.10(Predicted) |
| | 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Usage And Synthesis |
| Synthesis | A solution of 5,6-dimethoxy-indanone (19 g, 0.10 mol) in methanol (8 mL) is stirred under inert
atmosphere at room temperature. Slowly add NaOH flakes
(12.8 g, 0.32 mol) followed by N-benzyl-piperidine-4-carboxaldehyde (20.2 g, 0.10 mol) to the reaction mixture. The
mixture was stirred at room temperature for 3 h and progress
of the reaction was monitored by TLC (hexane:ethyl acetate;
1:1). Once the reaction is complete, the solid formed was
filtered, washed with 5 % acetic acid and then with methanol
and dried. The obtained solid (34 g) was taken into a round
bottom flask and refluxed with DMF (50 mL). Gradually cooled
to room temperature and stirred for 2 h, filtered the solid
formed, wash with chilled methanol to afford a pale yellow
crystalline solid 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (32.0 g, 84 %); m.p.: 175-177 °C.
 | | Uses | An impurity of Donepezil; an intermediate as an anti-Alzheimer agent. | | Uses | An impurity of Donepezil (D531750); an intermediate as an anti-Alzheimer's agent. |
| | 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Preparation Products And Raw materials |
|
