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| | 6-FLUORO-DL-TRYPTOPHAN Basic information |
| | 6-FLUORO-DL-TRYPTOPHAN Chemical Properties |
| Melting point | 280-285 °C (dec.)(lit.) | | Boiling point | 450.7±45.0 °C(Predicted) | | density | 1.2556 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated), Water (Slightly) | | form | crystalline | | pka | 2.22±0.10(Predicted) | | color | Almost white to beige | | CAS DataBase Reference | 7730-20-3(CAS DataBase Reference) |
| Hazard Codes | T | | Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | YN6850000 | | Hazard Note | Toxic | | HS Code | 29339900 |
| | 6-FLUORO-DL-TRYPTOPHAN Usage And Synthesis |
| Chemical Properties | almost white to beige powder | | Definition | ChEBI: 6-Fluoro-DL-tryptophan is an indolyl carboxylic acid. | | Biological Activity | 6-fluoro-dl-tryptophan is a serotonin (5-ht) synthesis inhibitor.serotonin or 5-hydroxytryptamine (5-ht), a monoamine neurotransmitter, is biochemically derived from tryptophan. serotonin is primarily present in the gastrointestinal tract, blood platelets, and the central nervous system of animals. serotonin is considered to be a contributor to feelings of well-being and happiness. | | in vitro | the potential competition was investigated between l-tryptophan (trp) and 6-fluoro-dl-tryptophan (6-f-trp). in equilibrium dialysis experiments, albumin bound about 80% of trp and 50% of 6-f-trp. competitive inhibition was assessed as the decrease in the apparent ka of trp in the presence of 6-f-trp, with no modification of the n value [1]. | | in vivo | rats werer administered 6-fluoro-dl-tryptophan (6f-trp) and its neurochemical effects on central catechole and indole were evaluated. results showed that neither norepinephrine nor dopamine and its major metabolites were affected by 6f-trp. with regard to serotonin (5-ht), 6f-trp could induce a transient depletion in all the studied brain areas, with a maximum of about 60-65% obtained between 1 and 3 hr. after 6 hr, 5-ht levels returned to control values. in addition, the 5-hydroxyindolacetic acid (5-hiaa) level was also reduced 3 hr after 6f-trp administration. a large dose-dependent increase in tryptophan was seen in the four brain areas, mainly due to an inhibition of tryptophan incorporation into protein, as demonstrated by experiments with mouse neuroblastoma cells [2]. | | references | [1] chanut, e. ,zini, r.,trouvin, j.h., et al. albumin binding and brain uptake of 6-fluoro-dl-tryptophan: competition with l-tryptophan. biochemical pharmacology 44(10), 2082-2085 (1992).
[2] chanut, e. ,trouvin, j.h.,bondoux, d., et al. metabolism of 6-fluoro-dl-tryptophan and its specific effects on the rat brain serotoninergic pathway. biochemical pharmacology 45(5), 1049-1057 (1992). |
| | 6-FLUORO-DL-TRYPTOPHAN Preparation Products And Raw materials |
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