ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Methylpyridine OXIDIZED NIFEDIPINE

OXIDIZED NIFEDIPINE

OXIDIZED NIFEDIPINE Basic information
Product Name:OXIDIZED NIFEDIPINE
Synonyms:Nifedipine-1; Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined;Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester;2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine;Divalproex Sodium Impurity 1;Nifedipine Nitrophenylpyridine Analog;dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate;Nifedipine impurity A (EP)
CAS:67035-22-7
MF:C17H16N2O6
MW:344.32
EINECS:
Product Categories:Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:67035-22-7.mol
OXIDIZED NIFEDIPINE Structure
OXIDIZED NIFEDIPINE Chemical Properties
Melting point 100-105 °C
Boiling point 443.7±45.0 °C(Predicted)
density 1.284±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form powder
pka1.55±0.29(Predicted)
color yellow
EPA Substance Registry System3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7)
Safety Information
Hazard Codes Xi
Risk Statements 41
Safety Statements 26-39
WGK Germany 2
MSDS Information
OXIDIZED NIFEDIPINE Usage And Synthesis
DescriptionDehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.
Chemical PropertiesPale Yellow Solid
UsesOxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
UsesThe main Nifedipine metabolite in human plasma
DefinitionChEBI: Dehydronifedipine is a phenylpyridine.
Biochem/physiol ActionsCYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.
OXIDIZED NIFEDIPINE Preparation Products And Raw materials
3-Pyridinecarboxaldehyde,2,4-dimethyl-(9CI) 2,4,6-TRIMETHYL-3,5-PYRIDINEDIMETHANOL 2,6-DIMETHYL-NICOTINIC ACID 6-Methylpyridine-3-carboxylic acid Dehydro nisoldipine-d6 3,5-PYRIDINECARBOXYLIC ACID, 3-METHYL ESTER OXIDIZED NIFEDIPINE Dehydronifedipine-D-6 Dehydro Nisoldipine 2,6-DIMETHYL-PYRIDINE-3-CARBALDEHYDE 5-Methyl-4-phenylpyridine-3-carboxaldehyde 4-Phenyl-2,6-dimethylpyridine 3-Pyridinemethanol,2,6-dimethyl-(9CI) 4-Phenylpyridine-3-carboxaldehyde 4-PHENYLNICOTINIC ACID 3,4,5-trimethylpyridine 4,6-DIMETHYLNICOTINIC ACID 2,6-DIMETHYL-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
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