ChemicalBook Product Catalog API Circulatory system drugs Antihypertensive drugs 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid

2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Basic information
Product Name:2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
Synonyms:(+)-[(2s,6r)-6-[[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid;2-[(2s)-6-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid;TEMOCAPRIL;(2E,5E)-2,6-bis(butylamino)-4-hepta-2,5-dienone;TEMOCAPRIL DISCONTINUED SEE T017301;Temocapil;(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Aci;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)- (9CI)
CAS:111902-57-9
MF:C23H28N2O5S2
MW:476.61
EINECS:
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:111902-57-9.mol
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Structure
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Chemical Properties
Melting point 1680C
alpha 23 +40° (c = 1.1 in DMF)
Boiling point 717.4±60.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka3.73±0.10(Predicted)
form Powder
color Crystalline
CAS DataBase Reference111902-57-9(CAS DataBase Reference)
Safety Information
MSDS Information
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Usage And Synthesis
Chemical PropertiesCrystalline Powder
UsesAngiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.
DefinitionChEBI: Temocapril is a dipeptide.
2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid Preparation Products And Raw materials
CHLORTALIDONE Butenafine hydrochloride NICKEL AND VANADIUM IN RESIDUAL FUEL OIL Temocapril hydrochloride 2-Thienylmethanethiol 2-[(2S)-6-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid 1-(2'-THIENYL)ETHYLMERCAPTAN (2S,6R)-6-[[1(s)-Ethoxycarbonyl-3-phenylpropyl]amino]-5-oxo-(2-thienyl)perhydro-1,4-thiazepine Thiophene L-Homophenylalanine ethyl ester Temocaprilat L-β-Homophenylalanine, HPLC 98% (2S,6R)-6-Amino-2-(2-thienyl)-1,4-thiazepan-5-one TEMOCAPRIL-D5
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