ChemicalBook Product Catalog Chemical Reagents Organic reagents aliphatic ketones 1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one Basic information
Product Name:1,4-Dioxaspiro[4.5]decan-8-one
Synonyms:cyclohexanedione monoethylene ketal;1,4-cyclohexanedione monoacetal;1 4-dioxiro[4.5]decan-8-one pharmaceutical intermediate;Substituted 1,2,4,9-tetrahydrospiro[carbazole-3,2'-[1,3]dioxane];1,4-Cyclohexanedione monoethlylene acetal;1,4-Cyclohexanedione monoethylene ketal for synthesis;4-Dioxaspiro[4.5]decan-8-one;Cyclohexane-1,4-dione monoethylene ketal
CAS:4746-97-8
MF:C8H12O3
MW:156.18
EINECS:610-352-2
Product Categories:ketone;Dioxanes & Dioxolanes;blocks;Carbonyl Compounds;Heterocycles;Dioxolanes;BuildingBlocks;Liquid Crystal intermediates;bc0001
Mol File:4746-97-8.mol
1,4-Dioxaspiro[4.5]decan-8-one Structure
1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties
Melting point 70-73 °C (lit.)
Boiling point 112C
density 1.0887 (rough estimate)
refractive index 1.4430 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in chloroform & methanol.
form Crystalline Powder or Crystals
color White to beige
Sensitive Moisture Sensitive
BRN 117631
InChIInChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
InChIKeyVKRKCBWIVLSRBJ-UHFFFAOYSA-N
SMILESO1C2(CCC(=O)CC2)OCC1
CAS DataBase Reference4746-97-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36/37/39-26
WGK Germany 3
F 8-10-21
Hazard Note Irritant
HS Code 29110000
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
1,4-Dioxaspiro[4.5]decan-8-one Usage And Synthesis
Chemical Properties1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals
Uses1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.
UsesIntermediates of Liquid Crystals
Uses1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.
Purification MethodsRecrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]
1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials
Preparation Products4,4-DIFLUOROCYCLOHEXANONE-->methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate-->4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-CYCLOHEXEN-1-YL]-MORPHOLINE-->Pramipexole impurity 7-->4-(TERT-BUTYLDIMETHYLSILYLOXY)CYCLOHEXA&-->4-Methoxycyclohexanol-->4-(Benzyloxy)cyclohexanone-->4-Pentylcyclohexanone-->INCB8761(PF-4136309)-->4-Propylcyclohexanone-->4-CYANOCYCLOHEXANONE CYCLIC ETHYLENE ACETAL-->4-Methoxycyclohexanon
7,9-BIS(2-BROMOBENZYL)-1,4-DIOXASPIRO[4.5]DECAN-8-ONE Diethylene glycol HEXANAL DIMETHYL ACETAL 2-ethyl-1,3-dioxolane 4-HYDROXYCYCLOHEXANONE 1,4-Dioxaspiro[4.5]decan-8-one (R)-5-HYDROXY-2-HEXANONE 2-Bromomethyl-1,3-dioxolane DIOXOPROMETHAZINE 1,1-DIMETHOXYCYCLOHEXANE 1,3-Dioxolane Decane 2,2-PENTAMETHYLENE-1,3-DIOXOLANE 1,4-Cyclohexanedione 2-METHYL-1,3-DIOXOLANE 3,3-DIMETHOXYHEXANE 2,2-DIMETHYL-1,3-DIOXOLANE DIOXOPROMETHAZINE HCL
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