ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 1-(5-Chloro-2-hydroxyphenyl)ethanone

1-(5-Chloro-2-hydroxyphenyl)ethanone

1-(5-Chloro-2-hydroxyphenyl)ethanone Basic information
Product Name:1-(5-Chloro-2-hydroxyphenyl)ethanone
Synonyms:JRH-01003, 1-(5-Chloro-2-hydroxyphenyl)ethanone, 97%;SALOR-INT L497495-1EA;2-Acetyl-4-chlorophenol;5'-Chloro-2'-Hydroxy Acetophenone 2'-Hydorxy-5'-Chloro Acetophenone;2'-Hydorxy-5'-ChloroAcetophenone;Acetophenone, 5'-chloro-2'-hydroxy-;Acetophenone,5-chloro-2-hydroxy-;5'-Chloro-2'-hydroxyacetophenone,99%
CAS:1450-74-4
MF:C8H7ClO2
MW:170.59
EINECS:215-916-8
Product Categories:Aromatic Acetophenones & Derivatives (substituted);Phenoles and thiophenoles;Adehydes, Acetals & Ketones;Chlorine Compounds;Phenols;C7 to C8;Carbonyl Compounds;Ketones
Mol File:1450-74-4.mol
1-(5-Chloro-2-hydroxyphenyl)ethanone Structure
1-(5-Chloro-2-hydroxyphenyl)ethanone Chemical Properties
Melting point 54-56 °C(lit.)
Boiling point 126-128 °C28 mm Hg(lit.)
density 1.2315 (rough estimate)
refractive index 1.5590 (estimate)
Fp 107-109°C/12mm
storage temp. Sealed in dry,Room Temperature
pka9.72±0.18(Predicted)
BRN 1365589
InChIKeyXTGCUDZCCIRWHL-UHFFFAOYSA-N
CAS DataBase Reference1450-74-4(CAS DataBase Reference)
NIST Chemistry ReferenceEthanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
Hazard Note Irritant
HS Code 29147000
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
1-(5-Chloro-2-hydroxyphenyl)ethanone Usage And Synthesis
Chemical Propertiesslightly yellow crystalline powder or chunks
Uses5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:
  • 6-chloro-2-methyl-4H-chrome-4-one
  • 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
  • 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
  • 2-styrenyl allyl ether
PreparationPreparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).
General Description5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.
1-(5-Chloro-2-hydroxyphenyl)ethanone Preparation Products And Raw materials
Preparation Products3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE-->1,2-BENZISOXAZOLE, 5-CHLORO-3-METHYL--->(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE-->1-(5-chloro-2-methoxyphenyl)ethan-1-ol-->(E)-1-(5-chloro-2-hydroxyphenyl)-3-(diMethylaMino)prop-2-en-1-one-->SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDIN]-4(3H)-ONE, 6-CHLORO--->2-(2-AMINO-1,3-THIAZOL-4-YL)-4-CHLOROPHENOL
5-Chloro-2-hydroxybenzophenone 6-CHLORO-3-FORMYLCHROMONE 1-(3,5-DICHLORO-2-HYDROXYPHENYL)-3-(2-FURYL)PROP-2-EN-1-ONE (+)-Griseofulvin (4S,4AS,6S,12AS)-7-CHLORO-4-DIMETHYLAMINO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE 6-CHLOROCHROMAN-4-ONE Demeclocycline hydrochloride 1-(5-Chloro-2-hydroxyphenyl)ethanone 5-CHLORO-BENZOFURAN-3-ONE METHYL 7-CHLORO-2-ETHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE METHYL 7-CHLORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE METHYL 7-CHLORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE MECLOCYCLINE SULFOSALICYLATE SALT 6-CHLORO-4-OXO-4H-CHROMENE-3-CARBALDEHYDE OXIME 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE LABOTEST-BB LT00244818 6,8-DICHLORO-3-FORMYLCHROMONE Chlortetracycline hydrochloride
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