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| | LAT-NET Basic information |
| Product Name: | LAT-NET | | Synonyms: | LATANOPROST ETHYL AMIDE;LAT-NET;N-ETHYL-9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR PROST 5Z-EN-1-AMIDE;13,14-Dihydro Bimatoprost;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethylhept-5-enamide;Bimatoprost Impurity 20;5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethyl-, (5Z)- | | CAS: | 607351-44-0 | | MF: | C25H39NO4 | | MW: | 417.58 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | LAT-NET Chemical Properties |
| Boiling point | 640.9±55.0 °C(Predicted) | | density | 1.095±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 50 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 200 μg/ml | | pka | 14.84±0.70(Predicted) |
| | LAT-NET Usage And Synthesis |
| Description | Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides. | | Uses | 13,14-Dihydro Bimatoprost can be used as reactant/reagent for preparation of nitrooxy prostamides for treatment of glaucoma. Analog or impurity of the drug Bimatoprost (B386800). | | Definition | ChEBI: Latanoprost ethyl amide is a prostanoid. |
| | LAT-NET Preparation Products And Raw materials |
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